2007
Striatal dopamine transporters correlate with simple reaction time in elderly subjects
van Dyck CH, Avery RA, MacAvoy MG, Marek KL, Quinlan DM, Baldwin RM, Seibyl JP, Innis RB, Arnsten AF. Striatal dopamine transporters correlate with simple reaction time in elderly subjects. Neurobiology Of Aging 2007, 29: 1237-1246. PMID: 17363113, PMCID: PMC3523216, DOI: 10.1016/j.neurobiolaging.2007.02.012.Peer-Reviewed Original ResearchConceptsStriatal DAT availabilityDAT availabilitySimple reaction timeStriatal dopamine transporter availabilityNigrostriatal dopamine systemNigrostriatal dopaminergic functionStriatal dopamine transporterMotor performanceDopamine transporter availabilityHealthy elderly individualsBrain uptakeDopaminergic functionAdvanced ageElderly subjectsContribution of ageTransporter availabilityHealthy volunteersElderly individualsDopamine systemCarbomethoxy-3betaNeuropsychological evaluationDopamine transporterMotor measuresNeurobiological substratesAge
2000
Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT
Laruelle M, Abi-Dargham A, van Dyck C, Gil R, D’Souza D, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biological Psychiatry 2000, 47: 371-379. PMID: 10704949, DOI: 10.1016/s0006-3223(99)00257-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBrain StemCarrier ProteinsCase-Control StudiesCocaineDopamineDopamine Plasma Membrane Transport ProteinsFemaleHumansIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNeostriatumNerve Tissue ProteinsSchizophreniaSerotoninSerotonin Plasma Membrane Transport ProteinsTomography, Emission-Computed, Single-PhotonConceptsAmphetamine-induced dopamine releaseStriatal dopamine transporterDopamine transporterControl subjectsDAT densityDopamine releaseNegative symptomsStriatal DAT densityDuration of illnessDopamine nerve terminalsHealthy control subjectsSerotonin transporter densityCohort of subjectsRelative deficitSingle photon emissionNeurodegenerative processesPostmortem studiesNerve terminalsSerotonin functionTrend-level associationReceptor radiotracerPatientsDopamine functionLower striatalTransporter density