2022
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J
Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.Peer-Reviewed Original ResearchConceptsSynaptic densityEarly Alzheimer's diseaseAlzheimer's diseaseCognitive performanceMajor pathological correlateGray matter volumePositron emission tomography (PET) imagingEmission Tomography ImagingPET imaging studiesIndividual cognitive domainsNeuropathologic studiesSignificant positive associationSynapse lossSynaptic alterationsPathological correlatesNeuropsychological test performanceMatter volumeCognitive impairmentSignificant associationImaging studiesDiseaseTomography imagingGlobal cognitionStrongest predictorPositive association
2011
IC‐P‐106: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's disease
van Dyck C, Brück A, Barcelos N, Planeta‐Wilson B, Benincasa A, MacAvoy M, Ding Y, Gelernter J, Carson R. IC‐P‐106: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's disease. Alzheimer's & Dementia 2011, 7: s51-s52. DOI: 10.1016/j.jalz.2011.05.071.Peer-Reviewed Original ResearchNormal first-degree relativesFirst-degree relativesNeuropsychological test performanceAlzheimer's diseaseGenetic riskDiseaseTest performanceP1‐387: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's disease
van Dyck C, Brück A, Barcelos N, Planeta‐Wilson B, Benincasa A, MacAvoy M, Ding Y, Gelernter J, Carson R. P1‐387: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's disease. Alzheimer's & Dementia 2011, 7: s236-s236. DOI: 10.1016/j.jalz.2011.05.668.Peer-Reviewed Original ResearchNormal first-degree relativesFirst-degree relativesNeuropsychological test performanceAlzheimer's diseaseGenetic riskDiseaseTest performance