Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study
Brumberg J, Küsters S, Al‐Momani E, Marotta G, Cosgrove KP, van Dyck C, Herrmann K, Homola GA, Pezzoli G, Buck AK, Volkmann J, Samnick S, Isaias IU. Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study. Annals Of Clinical And Translational Neurology 2017, 4: 632-639. PMID: 28904985, PMCID: PMC5590520, DOI: 10.1002/acn3.438.Peer-Reviewed Original ResearchLevodopa-induced dyskinesiaNicotinic acetylcholine receptorsSingle photon emissionNondyskinetic patientsDisease patientsCholinergic activityHealthy controlsAcetylcholine receptorsRegional cerebral metabolic activityDeoxyglucose positron emission tomographyExpression of dyskinesiaCerebral metabolic activityStriatal cholinergic activityParkinson's disease patientsBasal ganglia structuresStriatal binding potentialPositron emission tomographyDopaminergic responsivenessAffected sideClinical variablesDyskinetic subjectsCholinergic signalingGanglia structuresMolecular imaging studiesNeuronal excitability