2001
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin
Soares J, van Dyck C, Tan P, Zoghbi S, Garg P, Soufer R, Baldwin R, Fujita M, Staley J, Fu X, Amici L, Seibyl J, Innis R. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin. Psychiatry Research 2001, 106: 81-93. PMID: 11306248, DOI: 10.1016/s0925-4927(01)00071-3.Peer-Reviewed Original ResearchConceptsTest/retest reproducibilityPositron emission tomographyCortical brain areasIntra-class correlation coefficientRetest reproducibilityBrain areasBrain measuresHealthy human subjectsMean intra-class correlation coefficientOutcome measuresConstant infusionParent tracerBlood measurementsEmission tomographyNeuropsychiatric disordersPET measuresReceptorsHuman subjectsPET acquisitionMean intraEquilibrium imagingImaging methodInfusionBolusRT
1996
Human biodistribution and dosimetry of the SPECT D2 dopamine receptor radioligand [123I]IBF
van Dyck C, Seibyl J, Stubbs J, Zoghbi S, Wisniewski G, Baldwin R, Zea-Ponce Y, Charney D, Hoffer P, Innis R. Human biodistribution and dosimetry of the SPECT D2 dopamine receptor radioligand [123I]IBF. Nuclear Medicine And Biology 1996, 23: 9-16. PMID: 9004921, DOI: 10.1016/0969-8051(95)02003-9.Peer-Reviewed Original ResearchConceptsDopamine receptor radioligandBrain uptakeReceptor radioligandPromising SPECT agentMSv/MBqUrinary excretion fractionHigh brain uptakePeak brain uptakeUrinary bladder wallD2 dopamine receptorsHealthy human subjectsRapid urinary excretionSingle photon emissionMedical Internal Radiation Dose (MIRD) schemaHuman biodistributionUrinary excretionDopamine receptorsFavorable dosimetryBladder wallExcretion fractionRenal systemInjected activitySPECT agentHuman subjectsDose estimates