The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams T, Kelmendi B, Brake C, Gruner P, Badour C, Pittenger C. The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder. Chronic Stress 2018, 2: 2470547018758043. PMID: 29527593, PMCID: PMC5841259, DOI: 10.1177/2470547018758043.Peer-Reviewed Original ResearchOnset of symptomsOCD symptomatologyNeuronal hypertrophyNeuronal atrophyPathophysiological relationshipLimbic circuitsLimbic circuitryFrontal cortexDorsolateral striatumPsychosocial stressGoal-directed learningNeural abnormalitiesPsychiatric symptomatologyDorsomedial striatumPreclinical researchNonspecific factorsRole of stressSymptomsCompulsive disorderSymptomatologyStriatumOCD symptomsPathogenesisIndependent causeTraumatic incidents