2024
Topical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances.
Del Rosso J, Bunick C, Kircik L, Bhatia N. Topical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances. Journal Of Drugs In Dermatology 2024, 23: 438-445. PMID: 38834223, DOI: 10.36849/jdd.8318.Peer-Reviewed Original ResearchMeSH KeywordsAcne VulgarisAdministration, CutaneousAnti-Bacterial AgentsClindamycinDrug Resistance, BacterialHumansTreatment OutcomeConceptsAcne vulgarisTopical clindamycinTreatment of acne vulgarisManagement of acne vulgarisEmergence of antibiotic-resistant bacteriaAntibiotic-resistant bacteriaTopical agentsAnti-inflammatory propertiesTherapeutic advancesClindamycinClinical studiesTherapeutic outcomesClinical applicationAntimicrobial profileGram-positive bacteriaAnaerobic bacteriaMode of actionVulgarisMonotherapyPublished dataBacteriaTherapyAcneAntibiotics
2023
Acne accounts for an almost 2.5-fold higher proportion of dermatology visits among adult females compared to adult males in the United States: A study of the national ambulatory medical care survey from 2002–2016
Chang J, Nock M, Cohen J, Bunick C. Acne accounts for an almost 2.5-fold higher proportion of dermatology visits among adult females compared to adult males in the United States: A study of the national ambulatory medical care survey from 2002–2016. PLOS ONE 2023, 18: e0290763. PMID: 37733776, PMCID: PMC10513303, DOI: 10.1371/journal.pone.0290763.Peer-Reviewed Original ResearchMeSH KeywordsAcne VulgarisAdultAnti-Bacterial AgentsDermatologyFemaleHumansMaleRetrospective StudiesTetracyclinesUnited StatesYoung AdultConceptsTetracycline-class antibioticsDermatology visitsAdult acnePrescribed therapyNational Ambulatory Medical Care Survey dataNational Ambulatory Medical Care SurveyAge groupsAmbulatory Medical Care SurveyAdult female acneRetrospective database analysisEffectiveness of therapyAdult age groupsFemale acneJuvenile acneAdult female populationHealthcare utilizationHigher proportionDifferent pathogenesisCare SurveyAcne vulgarisAdult malesAcneAge 20Female populationDifferent presentationsEnsuring Dermatologists Practice Enhanced Antibiotic Stewardship With Sarecycline Mnemonic.
Borash J, Bunick C, Graber E. Ensuring Dermatologists Practice Enhanced Antibiotic Stewardship With Sarecycline Mnemonic. Journal Of Drugs In Dermatology 2023, 22: 1061. PMID: 37801533, DOI: 10.36849/jdd.7138.Peer-Reviewed Original ResearchSarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism
Lomakin I, Devarkar S, Patel S, Grada A, Bunick C. Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Research 2023, 51: 2915-2930. PMID: 36864821, PMCID: PMC10085706, DOI: 10.1093/nar/gkad103.Peer-Reviewed Original ResearchMeSH KeywordsAcne VulgarisAnti-Bacterial AgentsHumansPropionibacterium acnesProtein BiosynthesisRibosomesTetracyclinesTrends in Oral Antibiotic Use for Acne Treatment: A Retrospective, Population-Based Study in the United States, 2014 to 2016.
Grada A, Armstrong A, Bunick C, Salem R, Feldman S. Trends in Oral Antibiotic Use for Acne Treatment: A Retrospective, Population-Based Study in the United States, 2014 to 2016. Journal Of Drugs In Dermatology 2023, 22: 265-270. PMID: 36877883, DOI: 10.36849/jdd.7345.Peer-Reviewed Original ResearchMeSH KeywordsAcne VulgarisAnti-Bacterial AgentsDoxycyclineHumansMinocyclineRetrospective StudiesUnited StatesConceptsOral antibiotic useOral antibioticsAntibiotic useAntibiotic treatmentAcne treatmentHealth care claims dataOral antibiotic treatmentShort study durationIBM MarketScanPrimary outcomeGuideline recommendationsRetrospective studyAcne vulgarisRetrospective analysisClaims dataJ DrugsPatientsStudy durationAmerican AcademyTherapeutic classesSeparate occasionsDay gapMonthsAntibiotic resistanceAntibiotics
2021
Sarecycline treatment for acne vulgaris: Rationale for weight‐based dosing and limited impact of food intake on clinical efficacy
Grada A, Del Rosso JQ, Graber E, Bunick CG, Gold L, Moore AY, Baldwin H, Obagi Z, Damiani G, Carrothers T, McNamee B, Hanze E. Sarecycline treatment for acne vulgaris: Rationale for weight‐based dosing and limited impact of food intake on clinical efficacy. Dermatologic Therapy 2021, 35: e15275. PMID: 34923732, PMCID: PMC9286649, DOI: 10.1111/dth.15275.Peer-Reviewed Original ResearchMeSH KeywordsAcne VulgarisAdministration, OralAnti-Bacterial AgentsEatingHumansMinocyclineTetracyclinesTreatment OutcomeConceptsTetracycline-class antibioticsWeight-based dosingHigh-fat mealClinical efficacyAcne vulgarisFood intakeWeight-based dosing protocolAcne vulgaris patientsLow clinical efficacyExposure-response modelingPopulation pharmacokinetic modelingAcne vulgaris treatmentHigh-fat foodsDosing protocolDosing recommendationsInflammatory lesionsVulgaris patientsExtent of exposureClinical studiesImproved complianceGastrointestinal absorptionVulgaris treatmentDrug AdministrationPharmacokinetic modelingEfficacySpectrum of Antibiotic Activity and Its Relevance to the Microbiome
Grada A, Bunick CG. Spectrum of Antibiotic Activity and Its Relevance to the Microbiome. JAMA Network Open 2021, 4: e215357. PMID: 33914053, DOI: 10.1001/jamanetworkopen.2021.5357.Peer-Reviewed Original Research
2020
Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome
Batool Z, Lomakin IB, Polikanov YS, Bunick CG. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 20530-20537. PMID: 32817463, PMCID: PMC7456112, DOI: 10.1073/pnas.2008671117.Peer-Reviewed Original Research