2021
A neutrophil activation signature predicts critical illness and mortality in COVID-19
Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.Peer-Reviewed Original ResearchConceptsCritical illnessHealth system databaseNeutrophil activationCOVID-19Neutrophil activation signatureSevere COVID-19Intensive care unitGranulocyte colony-stimulating factorHigh mortality rateColony-stimulating factorSystem databaseHepatocyte growth factorClinical decompensationNeutrophil countImmune hyperactivationCare unitEarly elevationLipocalin-2Interleukin-8Longitudinal cohortClinical dataMortality ratePatientsIllnessActivation signature
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchMeSH KeywordsArrhythmias, CardiacCohort StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedPolysomnographyProspective StudiesSeverity of Illness IndexSleep Apnea SyndromesVeteransConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delay
2015
Gender differences in sleep disordered breathing: implications for therapy
Won C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy. Expert Review Of Respiratory Medicine 2015, 9: 221-231. PMID: 25739831, DOI: 10.1586/17476348.2015.1019478.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingSeverity of OSAUpper airway functionGender-related differencesAirway functionEndothelial dysfunctionLung functionComorbid conditionsSleep apneaTreatment optionsRespiratory stabilityImproved outcomesGender differencesGreater riskAdverse effectsWomenLimited dataAge increasesBreathingFemale presentationsHypertensionApneaAirwayPregnancy
2014
The impact of gender on timeliness of narcolepsy diagnosis.
Won C, Mahmoudi M, Qin L, Purvis T, Mathur A, Mohsenin V. The impact of gender on timeliness of narcolepsy diagnosis. Journal Of Clinical Sleep Medicine 2014, 10: 89-95. PMID: 24426826, PMCID: PMC3869076, DOI: 10.5664/jcsm.3370.Peer-Reviewed Original ResearchConceptsMultiple sleep latency testingLifestyle impairmentSymptom onsetConsecutive patientsUniversity Sleep Disorders CenterSleep latency testingSleep disorders centerEpworth Sleepiness ScaleCross-sectional studyTimeliness of diagnosisImpact of genderDelay diagnosisLatency testingNarcolepsy diagnosisNarcoleptic patientsDisorders CenterRelated symptomsSleepiness ScaleMedical conditionsPhysical activityWomen's healthObjective sleepinessSleep habitsPatientsDiagnosis