2022
In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits
Won C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits. Sleep Science And Practice 2022, 6: 4. DOI: 10.1186/s41606-022-00072-y.Peer-Reviewed Original ResearchObstructive sleep apneaProvider-patient communicationSleep apneaDaytime sleepinessPositive airway pressure therapyPhysician-patient visitsAirway pressure therapyExcessive daytime sleepinessEpworth Sleepiness ScaleQuality of lifePost-visit interviewsTherapy initiationAdult patientsAirway therapyPressure therapyPatient educationSleepiness ScalePrimary symptomsPatientsRoutine useScreening toolEDS symptomsVisitsPhysiciansApnea
2021
A neutrophil activation signature predicts critical illness and mortality in COVID-19
Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.Peer-Reviewed Original ResearchConceptsCritical illnessHealth system databaseNeutrophil activationCOVID-19Neutrophil activation signatureSevere COVID-19Intensive care unitGranulocyte colony-stimulating factorHigh mortality rateColony-stimulating factorSystem databaseHepatocyte growth factorClinical decompensationNeutrophil countImmune hyperactivationCare unitEarly elevationLipocalin-2Interleukin-8Longitudinal cohortClinical dataMortality ratePatientsIllnessActivation signature
2020
Circulating markers of angiogenesis and endotheliopathy in COVID‐19
Pine AB, Meizlish ML, Goshua G, Chang C, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Circulating markers of angiogenesis and endotheliopathy in COVID‐19. Pulmonary Circulation 2020, 10: 1-4. PMID: 33282193, PMCID: PMC7691906, DOI: 10.1177/2045894020966547.Peer-Reviewed Original ResearchCOVID-19 infectionMarkers of angiogenesisEndothelial injuryDisease severityCOVID-19-associated coagulopathyCritical COVID-19 infectionCOVID-19 pathogenesisCOVID-19COVID-19 diseaseEndothelial cell functionHospital mortalityMicrovascular complicationsCritical illnessElevated markersHospitalized patientsPatient populationFuture therapiesPlasma profilingSurvival analysisPatientsInfectionCell functionPotential targetInjuryMarkers
2019
Assessing Communication Between Physicians and Patients with Excessive Daytime Sleepiness Associated with Treated Obstructive Sleep Apnea: Insights from an Ethnographic Study of In-Office Visits
Won C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. Assessing Communication Between Physicians and Patients with Excessive Daytime Sleepiness Associated with Treated Obstructive Sleep Apnea: Insights from an Ethnographic Study of In-Office Visits. 2019, a1390-a1390. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1390.Peer-Reviewed Original ResearchChapter 6 Lung Diseases
Tobias L, Won C. Chapter 6 Lung Diseases. 2019, 121-151. DOI: 10.1016/b978-0-12-813014-8.00006-8.ChaptersSleep disordersLung diseaseCoexistent lung diseaseNormal sleep stateUnderlying pulmonary diseaseChronic lung diseaseComorbid sleep disordersCommon pulmonary disordersQuality of lifePulmonary diseaseRespiratory driveAirway anatomyPulmonary disordersSleep disturbancesCommon complaintSignificant abnormalitiesRespiratory diseaseCurrent evidencePatientsDiseaseDisordersRespiratory physiologySleep statesGas exchangeSymptoms
2018
Treating Sleep-Related Breathing Disorders
Won C, Mohsenin V, Kryger M. Treating Sleep-Related Breathing Disorders. 2018, 105-123. DOI: 10.1007/978-1-4939-8607-1_9.Peer-Reviewed Original ResearchPositive airway pressure therapySignificant symptomatic benefitAirway pressure therapySleep-disordered breathingMental health outcomesNeuropsychomotor functionsPAP therapyMainstay treatmentSymptomatic benefitPAP adherenceBreathing disordersPressure therapySide effectsHealth outcomesPatientsTherapyEffective alternativeAdherenceRobust evidenceTolerabilityBreathingSleep
2017
Impact of Sleep Breathing Disorders in Obese Critically Ill Patients
Al-Halawani M, Won C. Impact of Sleep Breathing Disorders in Obese Critically Ill Patients. 2017, 77-85. DOI: 10.1007/978-3-319-49253-7_8.Peer-Reviewed Original ResearchSleep breathing disordersBreathing disordersObesity hypoventilation syndromeObstructive sleep apneaSleep-disordered breathingIntensive care unitObese patientsHypoventilation syndromeIll patientsCare unitSleep apneaIll populationMajor causeObesePatientsDisordersRiskSerious riskApneaICUMorbidityComplicationsSyndromeMortalityBreathing
2016
The use of positive airway pressure therapy for treatment of resistant hypertension
Won C, Guilleminault C. The use of positive airway pressure therapy for treatment of resistant hypertension. Expert Review Of Cardiovascular Therapy 2016, 14: 505-511. PMID: 26671301, DOI: 10.1586/14779072.2016.1132626.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressure therapyObstructive sleep apneaAirway pressure therapyBlood pressure controlResistant hypertensionPressure therapyPressure controlSubgroup of patientsHigh-risk populationBlood pressureSleep apneaRisk factorsPathological mechanismsHypertensionNovel targetPatientsTherapyPotential mechanismsApneaMedicationsBreathingSleepTrials
2014
Sleep in Patients with Restrictive Lung Disease
Won CH, Kryger M. Sleep in Patients with Restrictive Lung Disease. Clinics In Chest Medicine 2014, 35: 505-512. PMID: 25156766, DOI: 10.1016/j.ccm.2014.06.006.ChaptersConceptsRestrictive lung diseaseLung diseaseObesity hypoventilation syndromeInterstitial lung diseasePathophysiology of sleepImpact of treatmentOverall prognosisVentilatory defectHypoventilation syndromeImpaired ventilationDaytime fatigueSleep disruptionRelated symptomsSleep disordersSleep qualityDiffusion impairmentNeuromuscular diseaseDiseasePatientsPathophysiologySleepHypoxemiaHypercarbiaPrognosisDysfunctionThe impact of gender on timeliness of narcolepsy diagnosis.
Won C, Mahmoudi M, Qin L, Purvis T, Mathur A, Mohsenin V. The impact of gender on timeliness of narcolepsy diagnosis. Journal Of Clinical Sleep Medicine 2014, 10: 89-95. PMID: 24426826, PMCID: PMC3869076, DOI: 10.5664/jcsm.3370.Peer-Reviewed Original ResearchConceptsMultiple sleep latency testingLifestyle impairmentSymptom onsetConsecutive patientsUniversity Sleep Disorders CenterSleep latency testingSleep disorders centerEpworth Sleepiness ScaleCross-sectional studyTimeliness of diagnosisImpact of genderDelay diagnosisLatency testingNarcolepsy diagnosisNarcoleptic patientsDisorders CenterRelated symptomsSleepiness ScaleMedical conditionsPhysical activityWomen's healthObjective sleepinessSleep habitsPatientsDiagnosis
2013
Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic Tool
Mahmoudi M, Won C, Mohsenin V. Narcolepsy-Characteristics of those in the Borderland-We Need a Better Diagnostic Tool. Journal Of Sleep Disorders Treatment & Care 2013, 02 DOI: 10.4172/2325-9639.1000106.Peer-Reviewed Original Research