2016
The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury
Song L, Papaioannou G, Zhao H, Luderer H, Miller C, Dall’Osso C, Nazarian R, Wagers A, Demay M. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology 2016, 157: 4066-4075. PMID: 27526034, PMCID: PMC5045513, DOI: 10.1210/en.2016-1474.Peer-Reviewed Original ResearchConceptsVDR KO miceVitamin D receptorWild-type miceKO miceResident macrophagesM-CSFM-CSF gene expressionVitamin D receptor ablationM-CSF-induced proliferationVitamin D receptor knockoutVitamin D receptor statusInflammatory response to injuryMacrophage colony-stimulating factorColony-stimulating factorPeritoneal resident macrophagesRecruitment of macrophagesTissue resident macrophagesRegulation of innateLigand-dependent actionsLiganded vitamin D receptorResponse to injuryCyclin D1 expressionMacrophage self-renewalParabiosis studiesMacrophage defect
2015
Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
Kolodin D, van Panhuys N, Li C, Magnuson A, Cipolletta D, Miller C, Wagers A, Germain R, Benoist C, Mathis D. Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice. Cell Metabolism 2015, 21: 543-557. PMID: 25863247, PMCID: PMC4747251, DOI: 10.1016/j.cmet.2015.03.005.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueTreg compartmentT cellsAccumulation of regulatory T cellsConventional CD4(+) T cellsCD4(+) T cellsRegulatory T cellsAdipose tissueMHC class II moleculesEpidemic of obesityClass II moleculesAntigen receptor repertoireWeeks of lifeConsequent metabolic abnormalitiesIndolent proliferationsVAT-TregRegulatory TLean miceMetabolic abnormalitiesLocal inflammationLymphoid organsSoluble mediatorsLean individualsMetabolic indicesPhenotypic conversion