Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
Hettmer S, Liu J, Miller C, Lindsay M, Sparks C, Guertin D, Bronson R, Langenau D, Wagers A. Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 20002-20007. PMID: 22135462, PMCID: PMC3250188, DOI: 10.1073/pnas.1111733108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell LineageCell ProliferationCell SeparationCell Transformation, NeoplasticGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMiceMice, Inbred C57BLMuscle CellsMuscle DevelopmentMuscle Fibers, SkeletalMuscle NeoplasmsMuscle, SkeletalRas ProteinsRatsSarcomaSignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsMechanistic target of rapamycinRhabdomyosarcoma cells in vitroHuman rhabdomyosarcomaTumor cell of originKirsten rat sarcoma viral oncogeneCyclin-dependent kinase inhibitor 2AIsolated skeletal muscle cellsRat sarcoma viral oncogeneChimeric mouse modelSoft tissue sarcomasIsolated satellite cellsCell of originMechanistic target of rapamycin signalingCells in vitroGene expression signaturesMesenchymal cell lineagesConsistent with activationSkeletal muscle cellsMyogenic featuresTissue-specific differentiation markersPleomorphic rhabdomyosarcomaCluster of genesInhibition of RasTarget of rapamycinHeterogeneous cancer