Intrathymic transplantation of young, engraftable thymic epithelial cells promotes the growth and regeneration of the aging thymus (TRAN1P.932)
KIM M, Miller C, Shadrach J, Wagers A, Serwold T. Intrathymic transplantation of young, engraftable thymic epithelial cells promotes the growth and regeneration of the aging thymus (TRAN1P.932). The Journal Of Immunology 2015, 194: 140.14-140.14. DOI: 10.4049/jimmunol.194.supp.140.14.Peer-Reviewed Original ResearchThymic epithelial cellsEpithelial cellsAged thymusIntrathymic transplantationProliferative capacityIn vitro colony forming assayT-cell recoveryT-cell lymphopeniaBone marrow transplantationT cell productionAge-related thymic involutionCell-intrinsic changesColony forming assayThymic regrowthMarrow transplantationThymic regenerationMolecular processesT cellsCell engraftmentThymic involutionCirculating factorsThymic growthHeterochronic parabiosisThymic declineAntigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
Kolodin D, van Panhuys N, Li C, Magnuson A, Cipolletta D, Miller C, Wagers A, Germain R, Benoist C, Mathis D. Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice. Cell Metabolism 2015, 21: 543-557. PMID: 25863247, PMCID: PMC4747251, DOI: 10.1016/j.cmet.2015.03.005.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueTreg compartmentT cellsAccumulation of regulatory T cellsConventional CD4(+) T cellsCD4(+) T cellsRegulatory T cellsAdipose tissueMHC class II moleculesEpidemic of obesityClass II moleculesAntigen receptor repertoireWeeks of lifeConsequent metabolic abnormalitiesIndolent proliferationsVAT-TregRegulatory TLean miceMetabolic abnormalitiesLocal inflammationLymphoid organsSoluble mediatorsLean individualsMetabolic indicesPhenotypic conversion