Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration
Painter M, Lutz A, Cheng Y, Latremoliere A, Duong K, Miller C, Posada S, Cobos E, Zhang A, Wagers A, Havton L, Barres B, Omura T, Woolf C. Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration. Neuron 2014, 83: 331-343. PMID: 25033179, PMCID: PMC4106408, DOI: 10.1016/j.neuron.2014.06.016.Peer-Reviewed Original ResearchConceptsImpairment of functional recoverySchwann cellsSensory neurons in vitroFunctional recoveryMyelin clearanceNeurons in vitroIntrinsic growth capacityTransplantation in vivoPeripheral nervous systemSchwann cell plasticityNerve injuryMacrophage recruitmentAge-associated declineNerve graftsSciatic nerveCell plasticityRegenerative capacityAxonal regenerationNervous systemMolecular interrogationNerveTranscriptional programsInjuryAgeClearanceVascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
Katsimpardi L, Litterman N, Schein P, Miller C, Loffredo F, Wojtkiewicz G, Chen J, Lee R, Wagers A, Rubin L. Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors. Science 2014, 344: 630-634. PMID: 24797482, PMCID: PMC4123747, DOI: 10.1126/science.1251141.Peer-Reviewed Original ResearchConceptsAssociated with reduced blood flowImproved olfactory discriminationAdult central nervous systemDecline of neurogenesisAged mouse brainAge-related declineCentral nervous systemNegative effects of agingNeural stem cellsOlfactory discriminationAge-related decline of neurogenesisCognitive functionAged miceIncreased neurogenesisNeural stem cell behaviorVascular remodelingSecreted factorsEffects of ageEnhanced neurogenesisYoung bloodStem cellsStem cell behaviorBlood flowNeurogenic nicheNervous system