Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration
Painter M, Lutz A, Cheng Y, Latremoliere A, Duong K, Miller C, Posada S, Cobos E, Zhang A, Wagers A, Havton L, Barres B, Omura T, Woolf C. Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration. Neuron 2014, 83: 331-343. PMID: 25033179, PMCID: PMC4106408, DOI: 10.1016/j.neuron.2014.06.016.Peer-Reviewed Original ResearchConceptsImpairment of functional recoverySchwann cellsSensory neurons in vitroFunctional recoveryMyelin clearanceNeurons in vitroIntrinsic growth capacityTransplantation in vivoPeripheral nervous systemSchwann cell plasticityNerve injuryMacrophage recruitmentAge-associated declineNerve graftsSciatic nerveCell plasticityRegenerative capacityAxonal regenerationNervous systemMolecular interrogationNerveTranscriptional programsInjuryAgeClearance