Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice
Kolodin D, van Panhuys N, Li C, Magnuson A, Cipolletta D, Miller C, Wagers A, Germain R, Benoist C, Mathis D. Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice. Cell Metabolism 2015, 21: 543-557. PMID: 25863247, PMCID: PMC4747251, DOI: 10.1016/j.cmet.2015.03.005.Peer-Reviewed Original ResearchConceptsVisceral adipose tissueTreg compartmentT cellsAccumulation of regulatory T cellsConventional CD4(+) T cellsCD4(+) T cellsRegulatory T cellsAdipose tissueMHC class II moleculesEpidemic of obesityClass II moleculesAntigen receptor repertoireWeeks of lifeConsequent metabolic abnormalitiesIndolent proliferationsVAT-TregRegulatory TLean miceMetabolic abnormalitiesLocal inflammationLymphoid organsSoluble mediatorsLean individualsMetabolic indicesPhenotypic conversion