2023
Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation
Bakhoum C, Madala S, Lando L, Yarmohammadi A, Long C, Miguez S, Chan A, Singer M, Jin A, Steren B, Adabifirouzjaei F, Goldbaum M, DeMaria A, Sarraf D, Bakhoum M. Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation. Journal Of The American Heart Association 2023, 12: e028853. PMID: 37577936, PMCID: PMC10492933, DOI: 10.1161/jaha.122.028853.Peer-Reviewed Original ResearchConceptsOptical coherence tomography scansAtrial fibrillationPerivascular lesionsTomography scanSpectral domain optical coherence tomography scansMacular spectral-domain optical coherence tomographySpectral-domain optical coherence tomographyMultivariable logistic regression modelCardiovascular risk factorsDomain optical coherence tomographyAtrial fibrillation groupCoronary artery diseaseIschemic heart diseaseSex-matched individualsCase-control studyPercentage of subjectsIschemic cardiovascular diseaseOptical coherence tomographyLogistic regression modelsCardiovascular workupCardiac emboliFibrillation groupSmoking historyArtery diseaseCarotid stenosisThe Role of Water in Uromodulin Regulation
Bakhoum C, Garimella P. The Role of Water in Uromodulin Regulation. Clinical Journal Of The American Society Of Nephrology 2023, 18: 985-987. PMID: 37418253, PMCID: PMC10564335, DOI: 10.2215/cjn.0000000000000233.Peer-Reviewed Original ResearchHypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children
Nugent J, Ghazi L, Yamamoto Y, Bakhoum C, Wilson F, Greenberg J. Hypertension, Blood Pressure Variability, and Acute Kidney Injury in Hospitalized Children. Journal Of The American Heart Association 2023, 12: e029059. PMID: 37119062, PMCID: PMC10227226, DOI: 10.1161/jaha.122.029059.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBlood pressure variabilityBlood pressure measurementsHospitalized childrenKidney injuryBlood pressurePressure variabilityIncident acute kidney injuryTime-updated Cox modelsMean blood pressureEnd-organ complicationsAnalysis of hypertensionAKI riskConclusions HypertensionHypertension thresholdInpatient hypertensionNormotensive patientsOrgan complicationsNonpharmacologic interventionsRetrospective cohortPediatric inpatientsMultivariable modelPediatric encountersHypertensionCox modelAssociation of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adultsDoes This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage
Ghazi L, Li F, Simonov M, Yamamoto Y, Nugent J, Greenberg J, Bakhoum C, Peixoto A, Wilson F. Effect of intravenous antihypertensives on outcomes of severe hypertension in hospitalized patients without acute target organ damage. Journal Of Hypertension 2022, 41: 288-294. PMID: 36583354, PMCID: PMC9799038, DOI: 10.1097/hjh.0000000000003328.Peer-Reviewed Original ResearchConceptsAcute target organ damageTarget organ damageSevere hypertensionOrgan damageIntravenous antihypertensivesBP elevationClinical outcomesMyocardial injuryTarget end-organ damageOverlap propensity scoreSevere BP elevationAcute kidney injuryBlood pressure reductionEnd-organ damageRisk of strokeInpatient hypertensionCardiovascular eventsIndex hospitalizationKidney injuryRetrospective studyHypertensionAntihypertensivesHospitalizationCox modelPatientsUrine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort
Bakhoum CY, Matheson MB, Greenberg JH, Furth SL, Ix JH, Garimella PS. Urine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort. Hypertension 2022, 79: 2298-2304. PMID: 35920156, PMCID: PMC9458625, DOI: 10.1161/hypertensionaha.122.19566.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseClinic blood pressureSystolic blood pressureBlood pressureUromodulin levelsKidney diseaseChild CohortMean systolicSodium intakeClinic systolic blood pressureMean systolic blood pressureHealthy pediatric cohortDiastolic blood pressureGlomerular filtration rateHigh blood pressureMultivariable linear regression modelsLoop of HenleUrine uromodulinDietary sodiumMedian ageSalt intakePediatric cohortFiltration rateGlomerular diseaseMultivariable modelRetinal Ischemic Perivascular Lesions, a Biomarker of Cardiovascular Disease
Madala S, Adabifirouzjaei F, Lando L, Yarmohammadi A, Long C, Bakhoum C, Goldbaum M, Sarraf D, DeMaria A, Bakhoum M. Retinal Ischemic Perivascular Lesions, a Biomarker of Cardiovascular Disease. Ophthalmology Retina 2022, 6: 865-867. PMID: 35589077, PMCID: PMC9464692, DOI: 10.1016/j.oret.2022.05.005.Peer-Reviewed Original ResearchRetinal vein occlusion is associated with stroke independent of underlying cardiovascular disease
Bakhoum C, Madala S, Long C, Adabifirouzjaei F, Freeman W, Goldbaum M, DeMaria A, Bakhoum M. Retinal vein occlusion is associated with stroke independent of underlying cardiovascular disease. Eye 2022, 37: 764-767. PMID: 35411111, PMCID: PMC9998396, DOI: 10.1038/s41433-022-02038-x.Peer-Reviewed Original ResearchConceptsRetinal vein occlusionPresence of RVORisk of strokeCardiovascular diseaseOdds ratioVein occlusionRisk factorsMultivariable logistic regression modelCoronary artery diseaseCross-sectional studyYears of ageLogistic regression modelsArtery diseaseDiabetes mellitusCarotid diseaseStroke developmentAtrial fibrillationLeading causeYoung subjectsEarly interventionStrokeOlder individualsConclusionsOur findingsDiseaseRiskScreening for Hypertension in Children With and Without Autism Spectrum Disorder
Nugent JT, Bakhoum C, Ghazi L, Greenberg JH. Screening for Hypertension in Children With and Without Autism Spectrum Disorder. JAMA Network Open 2022, 5: e226246. PMID: 35385092, PMCID: PMC8987909, DOI: 10.1001/jamanetworkopen.2022.6246.Peer-Reviewed Original ResearchRates of idiopathic childhood nephrotic syndrome relapse are lower during the COVID-19 pandemic
Crane C, Bakhoum C, Ingulli E. Rates of idiopathic childhood nephrotic syndrome relapse are lower during the COVID-19 pandemic. Pediatric Nephrology 2022, 37: 2679-2685. PMID: 35211788, PMCID: PMC8869345, DOI: 10.1007/s00467-022-05483-8.Peer-Reviewed Original ResearchConceptsSteroid-sensitive nephrotic syndromeRate of relapseNephrotic syndromeTransmission of infectionNS relapseGraphical abstractA higher resolution versionSingle-center retrospective chart reviewNephrotic syndrome relapseSteroid-sensitive NSRetrospective chart reviewLower relapse rateRate of hospitalizationInfection prevention measuresResultsOne hundred twentyCOVID-19 pandemicPre-pandemic periodChart reviewRelapse rateInfection preventionHundred twentyRelapseStudy periodSocial distancing periodConclusionsOur resultsDecreased rateNocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort
Bakhoum C, Katz R, Samuels J, Al-Rousan T, Furth S, Ix J, Garimella P. Nocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort. Clinical Journal Of The American Society Of Nephrology 2022, 17: 75-82. PMID: 34772729, PMCID: PMC8763165, DOI: 10.2215/cjn.09810721.Peer-Reviewed Original ResearchConceptsLeft ventricular mass indexHigher left ventricular mass indexVentricular mass indexChronic kidney diseaseMass indexDiastolic dippingGreater proteinuriaSodium intakeKidney diseaseFemale sexRisk factorsAmbulatory BP monitoringHigh sodium intakeNocturnal BP declineCross-sectional analysisSpline regression analysisNonglomerular CKDSystolic dippingNocturnal dippingBP declineBP monitoringMean ageBlack raceEchocardiographic dataChild Cohort
2021
Relationship between Retinal Vascular Occlusions and Cognitive Dementia in a Large Cross-Sectional Cohort
Chan AX, Bakhoum CY, Bangen KJ, Bakhoum MF. Relationship between Retinal Vascular Occlusions and Cognitive Dementia in a Large Cross-Sectional Cohort. American Journal Of Ophthalmology 2021, 226: 201-205. PMID: 33529587, PMCID: PMC9227960, DOI: 10.1016/j.ajo.2021.01.026.Peer-Reviewed Original ResearchConceptsRetinal vascular occlusionVascular occlusionCognitive dementiaHigh prevalenceMultiple logistic regression analysisCross-sectional studyLogistic regression analysisYears of ageElectronic medical recordsMedical visitsMedical recordsRisk factorsDiagnostic codesStudy populationInternational ClassificationSectional cohortSignificant associationDementiaOlder ageOcclusionStrokeAgeRegression analysisPrevalenceAssociationProteinuria and nocturnal blood pressure dipping in hypertensive children and adolescents
Bakhoum CY, Vuong KT, Carter CE, Gabbai FB, Ix JH, Garimella PS. Proteinuria and nocturnal blood pressure dipping in hypertensive children and adolescents. Pediatric Research 2021, 90: 876-881. PMID: 33504962, PMCID: PMC8313642, DOI: 10.1038/s41390-020-01315-3.Peer-Reviewed Original ResearchConceptsAmbulatory blood pressure monitoringBody mass indexAssociation of proteinuriaBlood pressureRisk factorsUrine PCRNocturnal blood pressure dippingKidney function declineNocturnal blood pressureAdverse cardiovascular outcomesElevated blood pressureModifiable risk factorsDiastolic blood pressureGlomerular filtration rateBlood pressure dippingBlood pressure monitoringSpot urine proteinHypertensive childrenImpactOur studyCardiovascular outcomesCreatinine ratioFunction declineMass indexProspective studyUrine protein
2020
The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial
Bakhoum CY, Anderson CAM, Juraschek SP, Rebholz CM, Appel LJ, Miller ER, Parikh CR, Obeid W, Rifkin DE, Ix JH, Garimella PS. The Relationship Between Urine Uromodulin and Blood Pressure Changes: The DASH-Sodium Trial. American Journal Of Hypertension 2020, 34: 154-156. PMID: 32856709, PMCID: PMC7951043, DOI: 10.1093/ajh/hpaa140.Peer-Reviewed Original ResearchConceptsSystolic blood pressureUrine uromodulinUromodulin levelsBlood pressureSodium dietSalt intakeDASH-Sodium trialHigh sodium dietHigh salt intakeHigh-salt dietSalt-induced hypertensionBlood pressure changesBody mass indexMultivariable linear regressionLoop of HenleHigher baseline levelsThick ascending limbFeeding periodGreater increaseSodium trialSalt dietDietary ApproachesMass indexRandomized trialsSBP change