2023
Association of clinical characteristics with urine uromodulin in children with chronic kidney disease
Faulkner S, Matheson M, Greenberg J, Garimella P, Furth S, Ix J, Bakhoum C. Association of clinical characteristics with urine uromodulin in children with chronic kidney disease. Pediatric Nephrology 2023, 38: 3859-3862. PMID: 36988691, PMCID: PMC10528151, DOI: 10.1007/s00467-023-05947-5.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseUrine uromodulinUromodulin levelsGlomerular diseaseKidney diseaseEtiology of CKDGraphical abstractA higher resolution versionOlder ageMultivariable linear regressionAge-specific referenceGreater kidney sizeHigh urine concentrationsRelationship of ageConclusionsAmong childrenTubular healthClinical characteristicsMedian eGFRMedian agePrimary outcomeKidney functionKidney sizeMultivariable modelChild CohortUrine concentrationsHealthy adults
2022
Nocturnal Dipping and Kidney Function Decline: Findings From the CKD in Children Study
Bakhoum C, Phadke M, Deng Y, Samuels J, Garimella P, Furth S, Wilson F, Ix J. Nocturnal Dipping and Kidney Function Decline: Findings From the CKD in Children Study. Kidney International Reports 2022, 7: 2446-2453. PMID: 36531891, PMCID: PMC9751682, DOI: 10.1016/j.ekir.2022.08.002.Peer-Reviewed Original ResearchChronic kidney diseaseGlomerular filtration rateIohexol glomerular filtration rateNocturnal dippingDipping statusKidney diseaseKidney failureEnd-stage kidney diseaseCox proportional hazards modelKidney failure eventsKidney function declineBlood pressure declineProportional hazards modelMore rapid declineCKiD cohortGFR declineCreatinine ratioKidney functionFunction declineMean ageUrine proteinFiltration rateGlomerular diseaseNondippingChild CohortUrine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort
Bakhoum CY, Matheson MB, Greenberg JH, Furth SL, Ix JH, Garimella PS. Urine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort. Hypertension 2022, 79: 2298-2304. PMID: 35920156, PMCID: PMC9458625, DOI: 10.1161/hypertensionaha.122.19566.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseClinic blood pressureSystolic blood pressureBlood pressureUromodulin levelsKidney diseaseChild CohortMean systolicSodium intakeClinic systolic blood pressureMean systolic blood pressureHealthy pediatric cohortDiastolic blood pressureGlomerular filtration rateHigh blood pressureMultivariable linear regression modelsLoop of HenleUrine uromodulinDietary sodiumMedian ageSalt intakePediatric cohortFiltration rateGlomerular diseaseMultivariable modelNocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort
Bakhoum C, Katz R, Samuels J, Al-Rousan T, Furth S, Ix J, Garimella P. Nocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort. Clinical Journal Of The American Society Of Nephrology 2022, 17: 75-82. PMID: 34772729, PMCID: PMC8763165, DOI: 10.2215/cjn.09810721.Peer-Reviewed Original ResearchConceptsLeft ventricular mass indexHigher left ventricular mass indexVentricular mass indexChronic kidney diseaseMass indexDiastolic dippingGreater proteinuriaSodium intakeKidney diseaseFemale sexRisk factorsAmbulatory BP monitoringHigh sodium intakeNocturnal BP declineCross-sectional analysisSpline regression analysisNonglomerular CKDSystolic dippingNocturnal dippingBP declineBP monitoringMean ageBlack raceEchocardiographic dataChild Cohort