Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum
Hegan PS, Chandhoke SK, Barone C, Egan M, Bähler M, Mooseker MS. Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum. Cytoskeleton 2016, 73: 163-179. PMID: 26972322, DOI: 10.1002/cm.21292.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIntestinal barrier functionBarrier functionSuperficial ulcerationKO miceFeatures of IBDDextran sulfate sodium-induced colitisIntestinal mucosal damageMucosal barrier functionSodium-induced colitisFecal occult bloodIntestinal epithelial cell apoptosisInflammatory bowel disease susceptibility genesEpithelial cell apoptosisSusceptibility genesMyosin IXbTransepithelial electrical resistanceNeutrophil infiltrationMucosal damageBowel diseaseOccult bloodSurface ulcerationDisease onsetIntestinal mucosaFocal lesions