2023
Two cold shock domain containing proteins trigger the development of infectious Trypanosoma brucei
Toh J, Nkouawa A, Dong G, Kolev N, Tschudi C. Two cold shock domain containing proteins trigger the development of infectious Trypanosoma brucei. PLOS Pathogens 2023, 19: e1011438. PMID: 37276216, PMCID: PMC10270622, DOI: 10.1371/journal.ppat.1011438.Peer-Reviewed Original ResearchConceptsCold shock domainMetacyclic parasitesRegulation of transcriptionMicrotubule-based movementProtozoan parasite Trypanosoma bruceiCold shock proteinsRNA-binding proteinC-terminal domainFamily of DNAN-terminal domainDNA damage repairParasite Trypanosoma bruceiSpecific binding motifAmino acid residuesMammalian infectivityNucleocytoplasmic transportDevelopmental programProcyclic parasitesTrypanosoma bruceiCSD2CSD1MRNA stabilityBiological functionsBinding motifBiological processes
2000
Determinants for cap trimethylation of the U2 small nuclear RNA are not conserved between Trypanosoma brucei and higher eukaryotic organisms
Günzl A, Bindereif A, Ullu E, Tschudi C. Determinants for cap trimethylation of the U2 small nuclear RNA are not conserved between Trypanosoma brucei and higher eukaryotic organisms. Nucleic Acids Research 2000, 28: 3702-3709. PMID: 11000261, PMCID: PMC110770, DOI: 10.1093/nar/28.19.3702.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBinding SitesCell LineConserved SequenceGuanosineMethylationMolecular Sequence DataMutationNucleic Acid ConformationPrecipitin TestsPromoter Regions, GeneticProtein BindingRegulatory Sequences, Nucleic AcidRibonucleoproteins, Small NuclearRNA CapsRNA, ProtozoanRNA, Small NuclearTransfectionTrypanosoma brucei bruceiConceptsCap trimethylationRibonucleoprotein particleEukaryotic organismsU2 snRNATrypanosoma bruceiU2 small nuclear RNA genesCap structureProtist parasite Trypanosoma bruceiSmall nuclear RNA genesCommon proteinsU2 small nuclear RNANuclear RNA genesHigher eukaryotic organismsRNA polymerase IIRNA polymerase IIISmall nuclear RNAMutant U2 snRNAsSet of proteinsParasite Trypanosoma bruceiSpliceosomal snRNPsRNP assemblyNuclear importPolymerase IIRNA genesSequence motifs