2021
Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology
Amaya C, Cameron C, Devarkar SC, Seager S, Gerstein MB, Xiong Y, Schlieker C. Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology. Journal Of Biological Chemistry 2021, 297: 100937. PMID: 34224731, PMCID: PMC8327139, DOI: 10.1016/j.jbc.2021.100937.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumER structural integrityGenetic epistasis analysisMembrane-bound organellesP62/sequestosome 1Endoplasmic reticulum morphologyImmunoglobulin-like domainsProtein light chain 3Light chain 3Epistasis analysisIdentical orthologsProteomic screenER morphologyHuman genomeMolecular playersNOMO1Protein foldingSequestosome 1Unknown functionER networkChain 3Lipid synthesisProper functionProtein 1Orthologs
2011
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier
Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 1763-1770. PMID: 21209336, PMCID: PMC3033243, DOI: 10.1073/pnas.1014402108.Peer-Reviewed Original ResearchConceptsProtein modifiersLysine residuesMammalian cellsUbiquitin-like protein Urm1Cellular apoptosis susceptibility proteinC-terminal glycine residueSpecific lysine residuesUb-like modifiersCovalent peptide bondPeroxiredoxin Ahp1Protein urmylationSusceptibility proteinUrm1S. cerevisiaeTarget proteinsGlycine residueThioester intermediateUnique substrateAdditional roleUrmylationAhp1Sulfur carrierOxidant treatmentResiduesDual role
2008
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway
Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 18255-18260. PMID: 19017811, PMCID: PMC2584574, DOI: 10.1073/pnas.0808756105.Peer-Reviewed Original Research