2007
Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes. Molecular Cell 2007, 25: 677-687. PMID: 17349955, PMCID: PMC7110467, DOI: 10.1016/j.molcel.2007.01.033.Peer-Reviewed Original ResearchConceptsDeubiquitinating enzymePapain-like foldCysteine protease domainLarge tegument proteinActive site cysteineActive site residuesBeta-hairpin loopExtensive hydrophobic interactionsSuicide substrateProtease moduleProtease domainTegument proteinsCysteine proteasesHairpin loopEnzymeThioether linkageUbUnique classHydrophobic interactionsMurine cytomegalovirusUbiquitinDomainProteinMembersCrystal structure
2005
A Deubiquitinating Activity Is Conserved in the Large Tegument Protein of the Herpesviridae
Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. A Deubiquitinating Activity Is Conserved in the Large Tegument Protein of the Herpesviridae. Journal Of Virology 2005, 79: 15582-15585. PMID: 16306630, PMCID: PMC1316044, DOI: 10.1128/jvi.79.24.15582-15585.2005.Peer-Reviewed Original Research