2016
The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations
Tsai PL, Zhao C, Turner E, Schlieker C. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. ELife 2016, 5: e16011. PMID: 27336722, PMCID: PMC4951196, DOI: 10.7554/elife.16011.Peer-Reviewed Original ResearchConceptsLamin B receptorInner nuclear membraneNuclear membraneHuman lamin B receptorPolytopic membrane proteinsGreenberg skeletal dysplasiaProtein turnover mechanismsHigher eukaryotesDisease-causing mutationsHuman cell linesNuclear laminaMutant proteinsMembrane proteinsMutant derivativesB receptorCholesterol auxotrophyTurnover mechanismsDisease-causing variantsPoint mutationsCholesterol synthesisEnzymatic activityCofactor NADPHFunction mechanismCell linesRapid degradation
2008
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway
Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 18255-18260. PMID: 19017811, PMCID: PMC2584574, DOI: 10.1073/pnas.0808756105.Peer-Reviewed Original Research