2016
Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study
Laudermilch E, Tsai PL, Graham M, Turner E, Zhao C, Schlieker C. Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study. Molecular Biology Of The Cell 2016, 27: 3964-3971. PMID: 27798237, PMCID: PMC5156537, DOI: 10.1091/mbc.e16-07-0511.Peer-Reviewed Original ResearchConceptsTorsin ATPasesNuclear envelopeNuclear pore complex biogenesisComplex biogenesisRegulatory cofactorsValuable experimental platformHuman genomeCRISPR/Observed phenotypeGenetic studiesFunctional linkATPasesCofactor functionElectron microscopy tomographyImmunogold labelingPhenotypic measuresCell linesCofactor systemBleb structuresBleb formationTOR2ANucleoporinsLULL1BiogenesisGenome
2015
The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1
Turner EM, Brown RS, Laudermilch E, Tsai PL, Schlieker C. The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1. Journal Of Virology 2015, 89: 8444-8452. PMID: 26041288, PMCID: PMC4524217, DOI: 10.1128/jvi.01143-15.Peer-Reviewed Original ResearchConceptsNuclear egressDouble knockout cell linesNuclear envelope dynamicsType II transmembrane proteinHerpes simplex virus 1HSV-1 nuclear egressKnockout cell linesSimplex virus 1Viral protein productionAAA ringGenome engineeringTransmembrane proteinLULL1CRISPR/Virus 1Unexpected roleProtein productionComprehensive geneticPhenotypic analysisHost cellsViral genomeEnvelope dynamicsEfficient growthCell linesHSV-1 production