Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier
Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 1763-1770. PMID: 21209336, PMCID: PMC3033243, DOI: 10.1073/pnas.1014402108.Peer-Reviewed Original ResearchConceptsProtein modifiersLysine residuesMammalian cellsUbiquitin-like protein Urm1Cellular apoptosis susceptibility proteinC-terminal glycine residueSpecific lysine residuesUb-like modifiersCovalent peptide bondPeroxiredoxin Ahp1Protein urmylationSusceptibility proteinUrm1S. cerevisiaeTarget proteinsGlycine residueThioester intermediateUnique substrateAdditional roleUrmylationAhp1Sulfur carrierOxidant treatmentResiduesDual role