2024
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.Peer-Reviewed Original ResearchConceptsBlocking CGRP signalingCGRP receptor componentsMigraine-like painCervical lymph nodesGap junction proteinPrimary headache disordersLymphatic vessel dysfunctionAcute migrainePharmacological blockadeLymph nodesHeadache disordersNeurological symptomsJunction proteinsCGRPLymphatic vesselsMeningeal lymphatic vesselsInducible knockoutVessel dysfunctionMigraineReceptor componentsHeadachePainPathophysiologyDysfunctionMice
2015
Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins
Schaefer SM, Gottschalk CH, Jabbari B. Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins. Toxins 2015, 7: 2615-2628. PMID: 26184313, PMCID: PMC4516932, DOI: 10.3390/toxins7072615.Peer-Reviewed Original ResearchConceptsChronic migraineBotulinum toxin injection therapyLarge healthcare costsBotulinum toxin therapyTreatment of migraineCommon neurological disorderToxin therapyInjection therapyPathophysiological mechanismsMigraine pathophysiologyHealthcare costsMigraineNeurological disordersAnimal dataBotulinum neurotoxinTherapyTreatmentInjection techniqueCurrent understandingMedicationsPathophysiology