2023
Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial
Chen T, Estrella M, Appel L, Surapaneni A, Köttgen A, Obeid W, Parikh C, Grams M. Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial. American Journal Of Kidney Diseases 2023, 83: 71-78. PMID: 37690632, DOI: 10.1053/j.ajkd.2023.05.017.Peer-Reviewed Original ResearchConceptsRisk of kidney failureChronic kidney diseaseAssociated with mortalityKidney diseaseKidney failureRisk of KFRTSerum uromodulinCohort of African American adultsReplacement therapyUromodulin levelsHigh riskUrine protein-creatinine ratioAfrican American adultsStored serum samplesGlomerular filtration rateBlood pressure goalsProtein-creatinine ratioAbstractText Label="RESULTS">Levels of uromodulinStudy of Kidney DiseaseAfrican American Study of Kidney DiseaseRandomized treatment groupsAssociation of baselineBaseline demographic factorsCox proportional hazards
2016
Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study
Greenberg JH, Zappitelli M, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Li S, Garg AX, Coca S, Parikh CR. Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study. JAMA Pediatrics 2016, 170: 1071-1078. PMID: 27618162, PMCID: PMC5476457, DOI: 10.1001/jamapediatrics.2016.1532.Peer-Reviewed Original ResearchConceptsLong-term kidney outcomesAcute kidney injuryChronic kidney diseasePediatric cardiac surgeryPerioperative acute kidney injuryPostoperative acute kidney injuryCardiac surgeryKidney diseaseKidney outcomesKidney injuryHigh short-term morbidityProspective multicenter cohort studySerum creatinine riseMulticenter cohort studyShort-term morbidityAge 1 monthOutcomes 5 yearsRenal outcomesPreoperative baselineCohort studyPediatric centersCardiopulmonary bypassCreatinine risePerson followPerson visitsA Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 482-490. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedApolipoprotein L1ApolipoproteinsBiomarkersCardiac Surgical ProceduresCase-Control StudiesCritical IllnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIntensive Care UnitsInterferon Regulatory Factor-2Lipoproteins, HDLMaleMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsRisk FactorsStatistics, NonparametricT-Box Domain ProteinsConceptsAcute kidney injuryGenome-wide association studiesSingle nucleotide polymorphismsKidney injuryGenetic lociAssociation studiesExploratory genome-wide association studyAcute kidney injury casesHospital acute kidney injuryCommon genetic variantsIndependent lociGene TBX1Chromosome 4Novel pathwayCritical illnessCardiac surgerySevere complicationsLociPatient populationTherapeutic advancesGenetic variantsGenotype imputationInjury casesExpedite recoveryInjuryYKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation
Puthumana J, Hall IE, Reese PP, Schröppel B, Weng FL, Thiessen-Philbrook H, Doshi MD, Rao V, Lee CG, Elias JA, Cantley LG, Parikh CR. YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation. Journal Of The American Society Of Nephrology 2016, 28: 661-670. PMID: 27451287, PMCID: PMC5280016, DOI: 10.1681/asn.2016010091.Peer-Reviewed Original ResearchConceptsYKL-40 concentrationsDonor kidneysYKL-40Renal recoveryDeceased donor kidney transplantationRisk of DGFAcute tubular necrosisDeceased kidney donorsDonor kidney transplantationProspective cohort studyPoor transplant outcomesDeceased donor kidneysOrgan procurement organizationsDonor biomarkersGraft functionKidney transplantationCohort studyGraft failureTransplant outcomesTubular injuryTubular necrosisRecipient outcomesKidney donorsProcurement biopsiesPrognostic biomarker
2015
Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes
Reese PP, Hall IE, Weng FL, Schröppel B, Doshi MD, Hasz RD, Thiessen-Philbrook H, Ficek J, Rao V, Murray P, Lin H, Parikh CR. Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes. Journal Of The American Society Of Nephrology 2015, 27: 1534-1543. PMID: 26374609, PMCID: PMC4849827, DOI: 10.1681/asn.2015040345.Peer-Reviewed Original ResearchConceptsDelayed graft functionRecipient delayed graft functionKidney injury molecule-1Graft functionInjury biomarkersDonor AKIDeceased donor organ qualityLiver-type fatty acidEarly allograft functionL-FABP concentrationRecipient renal functionUrinary NGAL concentrationsKidney transplant recipientsInjury molecule-1Kidney transplant outcomesAllograft functionUrinary NGALKidney injuryTransplant outcomesTransplant recipientsNGAL concentrationsRenal functionNeutrophil gelatinaseDeceased donorsIL-18Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery
Zhang WR, Garg AX, Coca SG, Devereaux PJ, Eikelboom J, Kavsak P, McArthur E, Thiessen-Philbrook H, Shortt C, Shlipak M, Whitlock R, Parikh CR. Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery. Journal Of The American Society Of Nephrology 2015, 26: 3123-3132. PMID: 25855775, PMCID: PMC4657830, DOI: 10.1681/asn.2014080764.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCanadaCardiac Surgical ProceduresCreatinineFemaleFollow-Up StudiesHumansInterleukin-10Interleukin-6Lipocalin-2LipocalinsMaleMiddle AgedPostoperative PeriodPreoperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsUnited StatesConceptsIL-10 concentrationsIL-6 concentrationsPlasma IL-6IL-6IL-10Cardiac surgeryHigh riskLower riskPeak IL-6 concentrationNeutrophil gelatinase-associated lipocalinPathophysiology of AKIPostoperative IL-6Long-term mortalityGelatinase-associated lipocalinBiomarkers of inflammationRisk of mortalityDose-dependent mannerHospital AKIAKI biomarkersCause mortalityPerioperative outcomesPreoperative concentrationsSerum creatinineDL increaseSecond tertile
2014
Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury
Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen‐Philbrook H, Ansari N, Coca SG, Garcia‐Tsao G, Parikh CR, Consortium F. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology 2014, 60: 622-632. PMID: 24375576, PMCID: PMC4065642, DOI: 10.1002/hep.26980.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAdultAgedAlbuminuriaBiomarkersCreatinineDiagnosis, DifferentialFatty Acid-Binding ProteinsFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansInterleukin-18KidneyLipocalin-2LipocalinsLiver CirrhosisMaleMembrane GlycoproteinsMiddle AgedProspective StudiesProto-Oncogene ProteinsReceptors, VirusSodiumConceptsAcute kidney injuryAcute tubular necrosisKidney injury molecule-1Neutrophil gelatinase-associated lipocalinHepatorenal syndromePrerenal azotemiaKidney injuryDifferential diagnosisUrinary biomarkersEtiology of AKIProgressive acute kidney injuryLiver-type fatty acidOptimal diagnostic cutoffInjury molecule-1Prospective cohort studyGelatinase-associated lipocalinAccurate differential diagnosisClinical decision makingNumber of biomarkersCohort studyTubular necrosisFractional excretionCommon etiologyInterleukin-18Kidney biomarkers
2013
Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery
Coca SG, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Krumholz HM, Shlipak MG, Parikh CR. Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery. Journal Of The American Society Of Nephrology 2013, 25: 1063-1071. PMID: 24357673, PMCID: PMC4005309, DOI: 10.1681/asn.2013070742.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Long-term mortalityIL-18Urinary biomarkersClinical AKICardiac surgeryHighest tertileUrinary neutrophil gelatinase-associated lipocalinProspective long-term followNeutrophil gelatinase-associated lipocalinContinuous net reclassification improvementInjury molecule-1Kidney injury biomarkersPostoperative day 1Gelatinase-associated lipocalinImmediate postoperative periodAdditional prognostic informationLong-term followNet reclassification improvementMortality 3 yearsLiver fatty acidAKI cohortCause mortalityHospital outcomesKidney injury
2011
Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery
Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1748-1757. PMID: 21836143, PMCID: PMC3171945, DOI: 10.1681/asn.2010121302.Peer-Reviewed Original ResearchConceptsPlasma neutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalinUrine IL-18Acute kidney injuryUrine neutrophil gelatinase-associated lipocalinPlasma NGAL levelsIL-18Net reclassification improvementCardiac surgeryKidney injuryNGAL levelsPoor outcomeIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresMulticenter cohort studyGelatinase-associated lipocalinAdult cardiac surgeryReceiver-operating characteristic curveAdverse patient outcomesClinical prediction modelPostoperative biomarkersUnit stayHospital stayMultivariable adjustmentPostoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery
Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1737-1747. PMID: 21836147, PMCID: PMC3171944, DOI: 10.1681/asn.2010111163.Peer-Reviewed Original ResearchConceptsUrine neutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalinUrine IL-18Acute kidney injurySevere acute kidney injuryUrine NGAL levelsPediatric cardiac surgeryIL-18NGAL levelsCardiac surgeryPoor outcomeHospital stayKidney injuryPlasma neutrophil gelatinase-associated lipocalinIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresPlasma NGAL levelsLonger hospital stayMulticenter cohort studyGelatinase-associated lipocalinCongenital cardiac lesionsNet reclassification improvementPostoperative biomarkersUnit stay