Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery
Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1748-1757. PMID: 21836143, PMCID: PMC3171945, DOI: 10.1681/asn.2010121302.Peer-Reviewed Original ResearchConceptsPlasma neutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalinUrine IL-18Acute kidney injuryUrine neutrophil gelatinase-associated lipocalinPlasma NGAL levelsIL-18Net reclassification improvementCardiac surgeryKidney injuryNGAL levelsPoor outcomeIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresMulticenter cohort studyGelatinase-associated lipocalinAdult cardiac surgeryReceiver-operating characteristic curveAdverse patient outcomesClinical prediction modelPostoperative biomarkersUnit stayHospital stayMultivariable adjustmentPostoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery
Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1737-1747. PMID: 21836147, PMCID: PMC3171944, DOI: 10.1681/asn.2010111163.Peer-Reviewed Original ResearchConceptsUrine neutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalinUrine IL-18Acute kidney injurySevere acute kidney injuryUrine NGAL levelsPediatric cardiac surgeryIL-18NGAL levelsCardiac surgeryPoor outcomeHospital stayKidney injuryPlasma neutrophil gelatinase-associated lipocalinIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresPlasma NGAL levelsLonger hospital stayMulticenter cohort studyGelatinase-associated lipocalinCongenital cardiac lesionsNet reclassification improvementPostoperative biomarkersUnit stay