2022
Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging
Chung KKH, Zhang Z, Kidd P, Zhang Y, Williams ND, Rollins B, Yang Y, Lin C, Baddeley D, Bewersdorf J. Fluorogenic DNA-PAINT for faster, low-background super-resolution imaging. Nature Methods 2022, 19: 554-559. PMID: 35501386, PMCID: PMC9133131, DOI: 10.1038/s41592-022-01464-9.Peer-Reviewed Original ResearchConceptsSlow imaging speedSuper-resolution imagingSuper-resolution microscopy methodsDNA-PAINTOptical sectioningImaging speedFast imagingNanometer resolutionDNA-based points accumulationHigh-fidelity imagesUnbound fluorophoresMicroscopy methodsDocking strandsHigh backgroundPoint accumulationNanoscale topographyProbe
2008
Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity
Lin C, Nangreave JK, Li Z, Liu Y, Yan H. Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity. Nanomedicine 2008, 3: 521-528. PMID: 18694314, DOI: 10.2217/17435889.3.4.521.Peer-Reviewed Original ResearchConceptsHybridization chain reactionSignal amplificationSelf-assembled DNAMultiplexed biosensingFluorescence enhancementNanomedical applicationsSensitive detectionDetection probeConfocal fluorescence microscopySignal amplifierImprovement of sensitivityDetection sensitivityOrders of magnitudeEnhanced sensitivityBiosensorBiosensingFluorescence microscopyNanoarraysSuccessful detectionReactionMicroscopyVersatilityDetection targetProbeDetection
2007
Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing
Lin C, Liu Y, Yan H. Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano Letters 2007, 7: 507-512. PMID: 17298017, PMCID: PMC1963466, DOI: 10.1021/nl062998n.Peer-Reviewed Original ResearchConceptsDifferent molecular probesMultiplexed biosensingNucleic acid probesSensitive detectionMolecular probesMultiplexed detectionAcid probesDNA hybridizationBinding reactionNucleic acidsFluorescent dyeInterprobe distanceDisease diagnosticsSensor platformMoleculesMultiple DNA sequencesTwo-dimensional arraySmall amountBioconjugationBiosensingNanoarraysAptamerDyeProbeNanotiles