2008
Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity
Lin C, Nangreave JK, Li Z, Liu Y, Yan H. Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity. Nanomedicine 2008, 3: 521-528. PMID: 18694314, DOI: 10.2217/17435889.3.4.521.Peer-Reviewed Original ResearchConceptsHybridization chain reactionSignal amplificationSelf-assembled DNAMultiplexed biosensingFluorescence enhancementNanomedical applicationsSensitive detectionDetection probeConfocal fluorescence microscopySignal amplifierImprovement of sensitivityDetection sensitivityOrders of magnitudeEnhanced sensitivityBiosensorBiosensingFluorescence microscopyNanoarraysSuccessful detectionReactionMicroscopyVersatilityDetection targetProbeDetection
2007
Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing
Lin C, Liu Y, Yan H. Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano Letters 2007, 7: 507-512. PMID: 17298017, PMCID: PMC1963466, DOI: 10.1021/nl062998n.Peer-Reviewed Original ResearchConceptsDifferent molecular probesMultiplexed biosensingNucleic acid probesSensitive detectionMolecular probesMultiplexed detectionAcid probesDNA hybridizationBinding reactionNucleic acidsFluorescent dyeInterprobe distanceDisease diagnosticsSensor platformMoleculesMultiple DNA sequencesTwo-dimensional arraySmall amountBioconjugationBiosensingNanoarraysAptamerDyeProbeNanotiles