2020
DNA-Origami-Based Fluorescence Brightness Standards for Convenient and Fast Protein Counting in Live Cells
Williams ND, Landajuela A, Kasula RK, Zhou W, Powell JT, Xi Z, Isaacs FJ, Berro J, Toomre D, Karatekin E, Lin C. DNA-Origami-Based Fluorescence Brightness Standards for Convenient and Fast Protein Counting in Live Cells. Nano Letters 2020, 20: 8890-8896. PMID: 33164530, PMCID: PMC7726105, DOI: 10.1021/acs.nanolett.0c03925.Peer-Reviewed Original ResearchConceptsCopies of proteinsBrightness standardsFluorescence microscopyProtein countingMammalian cellsFluorescent proteinCopy numberLive cellsConventional quantification techniquesBiological LaboratoryFluorescence microscopeProteinDNA origamiVersatile toolCellsBiologyCurrent quantification methodsCopiesOrganic dyes
2012
Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA
Lin C, Jungmann R, Leifer AM, Li C, Levner D, Church GM, Shih WM, Yin P. Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA. Nature Chemistry 2012, 4: 832-839. PMID: 23000997, PMCID: PMC3523708, DOI: 10.1038/nchem.1451.Peer-Reviewed Original Research
2008
Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity
Lin C, Nangreave JK, Li Z, Liu Y, Yan H. Signal amplification on a DNA-tile-based biosensor with enhanced sensitivity. Nanomedicine 2008, 3: 521-528. PMID: 18694314, DOI: 10.2217/17435889.3.4.521.Peer-Reviewed Original ResearchConceptsHybridization chain reactionSignal amplificationSelf-assembled DNAMultiplexed biosensingFluorescence enhancementNanomedical applicationsSensitive detectionDetection probeConfocal fluorescence microscopySignal amplifierImprovement of sensitivityDetection sensitivityOrders of magnitudeEnhanced sensitivityBiosensorBiosensingFluorescence microscopyNanoarraysSuccessful detectionReactionMicroscopyVersatilityDetection targetProbeDetection