Early-Onset Vascular Dementia in a 43-Year-Old Man with Accelerated Atherosclerotic Disease, Elevated Lipoprotein (a), and a Missense DNAJC5 Variant with Potential Association to Adult-Onset Ceroid Lipofuscinosis
Faruq RN, D’Silva P, Lau FD, Zhao C, Majumdar S. Early-Onset Vascular Dementia in a 43-Year-Old Man with Accelerated Atherosclerotic Disease, Elevated Lipoprotein (a), and a Missense DNAJC5 Variant with Potential Association to Adult-Onset Ceroid Lipofuscinosis. Case Reports In Neurology 2021, 13: 565-571. PMID: 34720963, PMCID: PMC8460928, DOI: 10.1159/000518194.Peer-Reviewed Case Reports and Technical NotesEarly-onset dementiaNew infarctsElevated lipoproteinVascular dementiaRisk factorsMemory lossCeroid lipofuscinosisAccelerated atherosclerotic diseaseEarly vascular dementiaModifiable risk factorsProgressive memory lossMissense variantsDNAJC5 geneBilateral ICABilateral PCACardiac echocardiogramAccelerated atherosclerosisAntiplatelet agentsCerebrovascular infarctsAtherosclerotic diseaseCSF studiesLeft PCASevere stenosisMMA levelsInfarcts