2011
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL
Hanash A, Kappel L, Yim N, Nejat R, Goldberg G, Smith O, Rao U, Dykstra L, Na I, Holland A, Dudakov J, Liu C, Murphy G, Leonard W, Heller G, van den Brink M. Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood 2011, 118: 446-455. PMID: 21596854, PMCID: PMC3138694, DOI: 10.1182/blood-2010-07-294785.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Knockdown TechniquesGraft vs Host DiseaseGraft vs Leukemia EffectHumansImmunity, InnateInterleukin-21 Receptor alpha SubunitInterleukinsLymphocytes, Tumor-InfiltratingMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAMice, KnockoutOrgan SpecificitySignal TransductionTissue DonorsT-LymphocytesTransplantation ImmunologyConceptsSeparation of GVHDDonor T cellsKO T cellsIL-21T cellsTissue-specific modulationGastrointestinal GVHDCytokine productionWild-type donor T cellsDonor regulatory T cellsTh cell cytokine productionPeripheral T cell functionMesenteric lymph nodesRegulatory T cellsTh cell functionIL-21 signalingInflammatory cytokine productionBM transplantation modelT cell functionLymphoma responseLymph nodesProinflammatory cytokinesTransplantation outcomesTransplantation modelGVHD
2007
Hepatitis C Virus Triggers Apoptosis of a Newly Developed Hepatoma Cell Line Through Antiviral Defense System
Zhu H, Dong H, Eksioglu E, Hemming A, Cao M, Crawford J, Nelson D, Liu C. Hepatitis C Virus Triggers Apoptosis of a Newly Developed Hepatoma Cell Line Through Antiviral Defense System. Gastroenterology 2007, 133: 1649-1659. PMID: 17983809, DOI: 10.1053/j.gastro.2007.09.017.Peer-Reviewed Original ResearchConceptsTumor necrosis factor-related apoptosis-inducing ligandHCV infectionViral infectionHepatoma cell lineHCV isolatesJFH-1New hepatoma cell lineViral replicationCell linesMechanisms of HCVAcute HCV infectionChronic viral infectionsPathogenesis of HCVNovel human hepatoma cell lineInterferon response factor 3Antiviral defense systemNecrosis factor-related apoptosis-inducing ligandType I interferon inductionFactor-related apoptosis-inducing ligandExpression of interferonHost immune systemHepatocellular carcinoma tissuesI interferon inductionDeath receptor 5Induction of interferon