2012
Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer
Meng L, Yang L, Zhao X, Zhang L, Zhu H, Liu C, Tan W. Targeted Delivery of Chemotherapy Agents Using a Liver Cancer-Specific Aptamer. PLOS ONE 2012, 7: e33434. PMID: 22558072, PMCID: PMC3338807, DOI: 10.1371/journal.pone.0033434.Peer-Reviewed Original ResearchConceptsAptamer-drug conjugatesCancer-specific aptamersAntitumor agent doxorubicinDOX conjugatesIntercalation methodAptamerCell viability testTargeted deliveryConjugatesCancer cellsTarget proteinsAgent doxorubicinPotential candidateCell linesDOXEfficiency of chemotherapyLiver cancer cellsNonspecific uptakeTarget specificityAvailable aptamersCarcinoma cell linesChemotherapy agentsHepatocellular carcinoma cell linesHuman hepatocellular carcinoma cell linePromising method
2011
Molecular aptamers for drug delivery
Tan W, Wang H, Chen Y, Zhang X, Zhu H, Yang C, Yang R, Liu C. Molecular aptamers for drug delivery. Trends In Biotechnology 2011, 29: 634-640. PMID: 21821299, PMCID: PMC3218254, DOI: 10.1016/j.tibtech.2011.06.009.Peer-Reviewed Original ResearchConceptsVariety of nanomaterialsAptamer-mediated deliveryRapid tissue penetrationEasy chemical synthesisDNA micellesActive targetingGold nanorodsCarbon nanotubesMolecular aptamersChemical synthesisDrug deliveryDNA hydrogelsMolecular probesTissue penetrationAttractive moleculeAptamerPowerful technologyRecent progressWidespread applicationNanomaterialsTreatment of cancerNanorodsHigh affinityNanotubesDelivery