2011
Survivin inhibition is critical for Bcl‐2 family inhibitor, ABT‐263 to induce apoptosis in liver cancer cells
zhao X, Ogunwobi O, Nelson D, Liu C. Survivin inhibition is critical for Bcl‐2 family inhibitor, ABT‐263 to induce apoptosis in liver cancer cells. The FASEB Journal 2011, 25: 563.13-563.13. DOI: 10.1096/fasebj.25.1_supplement.563.13.Peer-Reviewed Original ResearchYM-155Liver cancer cellsABT-263HCC cellsProtein expressionCancer cellsABT-263 treatmentNormal hepatocytesMechanism of actionHCC cell apoptosisBcl-2 inhibitorsSurvivin protein expressionBcl-2 family inhibitorsHCC managementSignificant apoptotic effectHigh dosesLow dosesSurvivin expressionNovel Bcl-2 inhibitorSurvivin inhibitionSurvivin inhibitorChemotherapeutic alternativesInhibitory effectCell apoptosisSurvivin siRNA
2003
Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway
Zhu H, Liu C. Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway. Journal Of Virology 2003, 77: 5493-5498. PMID: 12692250, PMCID: PMC153991, DOI: 10.1128/jvi.77.9.5493-5498.2003.Peer-Reviewed Original ResearchConceptsInterferon-stimulated genesHepatitis C virusInterleukin-1Antiviral activityHCV subgenomic RNA replicationDirect antiviral activityIL-1 productionReplicon cell linesNovel antiviral pathwayViral protein expressionViral clearanceC virusChronic infectionInflammatory processRNA replicationExtracellular-regulated kinase (ERK) pathwayAntiviral pathwaysInhibitory effectProtein expressionCell linesKinase pathwayKinase activationActivationPatientsInfection