2015
Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in Mice
Nguyen H, Heinrichs J, Fu J, Wu Y, Bastian D, Schutt S, Daenthanasanmak A, Dany M, Liu C, Fairlie D, Tomlinson S, Yu X. Targeting Host Complement C3a/C5a Receptors to Control of Acute Graft-Versus-Host Disease in Mice. Blood 2015, 126: 3076. DOI: 10.1182/blood.v126.23.3076.3076.Peer-Reviewed Original ResearchC3aR/C5aRAntigen presenting cellsDonor T cellsT cellsGVL activityHost diseaseC5aR signalingAlloreactive donor T cellsDonor T cell activationDonor T-cell responsesHost antigen presenting cellsAllogeneic hematopoietic cell transplantationComplement systemAcute Graft-VersusControl of GVHDHost hematopoietic cellsDevelopment of GVHDGVHD target organsAdaptive immune cellsHematopoietic cell transplantationEffector T cellsT cell responsesTotal body irradiationAlloreactive T cellsPro-inflammatory cytokines
2012
CD24-Siglec-G Interaction Plays an Important in Reducing Experimental Graft-Versus-Host Disease (GVHD)
Toubai T, Evers R, Sun Y, Tawara I, Liu C, Tamaki H, Mathewson N, Nieves E, Bassetti M, Zheng P, Liu Y, Reddy P. CD24-Siglec-G Interaction Plays an Important in Reducing Experimental Graft-Versus-Host Disease (GVHD). Blood 2012, 120: 453. DOI: 10.1182/blood.v120.21.453.453.Peer-Reviewed Original ResearchHost antigen presenting cellsAntigen presenting cellsBALB/c donorsT cellsWT B6Allogeneic BMTImmunoreceptor tyrosine-based inhibitory motifWorse survivalSerum levelsImmune activationBM chimerasDonor T cell expansionAllogeneic T-cell responsesT cell responsesBALB/c T cellsPro-inflammatory cytokinesT cell expansionRelevant murine modelRole of SiglecsC donorsIg-like lectinsIntensity of conditioningGraft-VersusGVHD mortalityHigher GVHD
2009
A Crucial Role for Antigen Presenting Cells in Donor CD4+CD25+ Regulatory T Cell Mediated Suppression of Experimental Gvhd.
Tawara I, Toubai T, Malter C, Sun Y, Nieves E, Lowler K, Liu C, Ferrara J, Reddy P. A Crucial Role for Antigen Presenting Cells in Donor CD4+CD25+ Regulatory T Cell Mediated Suppression of Experimental Gvhd. Blood 2009, 114: 688. DOI: 10.1182/blood.v114.22.688.688.Peer-Reviewed Original ResearchHost antigen presenting cellsAntigen presenting cellsGVHD mortalityGVHD protectionT cellsWT recipientsIL-10Effector phaseDonor TregsExperimental GVHDAllo-antigenB6 animalsPresenting cellsClass IIProfessional antigen presenting cellsLack of TregsMaintenance of GVHDRegulation of GVHDResponse of TregsExpansion of CD8Target tissuesRegulatory T cellsT cell effectorsClass II expressionHost target tissuesIkaros Deficiency Enhances Notch Signaling in Host Antigen Presenting Cells and Differentially Regulates Gvhd and GVL Responses After Experimental BMT.
Toubai T, Sun Y, Tawara I, Malter C, Lowler K, Nieves E, Liu C, Maillard I, Winandy S, Reddy P. Ikaros Deficiency Enhances Notch Signaling in Host Antigen Presenting Cells and Differentially Regulates Gvhd and GVL Responses After Experimental BMT. Blood 2009, 114: 690. DOI: 10.1182/blood.v114.22.690.690.Peer-Reviewed Original ResearchDendritic cellsHost APCsGVL responseT cellsDonor T cell expansionHost antigen presenting cellsAllo-stimulatory capacityB6 dendritic cellsCertain dendritic cellsModel of GVHDNumber of PDCsInduction of graftAllogeneic T cellsT cell expansionAntigen presenting cellsComprehensive cancer centerBlockade of NotchStrain-independent mannerΓ-secretase inhibitorPutative molecular targetsMichigan Comprehensive Cancer CenterRate of apoptosisAcute GVHDGvH responseGVHD response
2006
Secondary Lymphoid Tissues Are Not Required for the Induction of GVHD Following Allogeneic BMT: A Shifting Paradigm for T Cell Allo-Activation.
Silva I, Olkiewicz K, Fisher J, Chaudhary M, Vannella K, Deurloo D, Choi S, Liu C, Cooke K. Secondary Lymphoid Tissues Are Not Required for the Induction of GVHD Following Allogeneic BMT: A Shifting Paradigm for T Cell Allo-Activation. Blood 2006, 108: 3170. DOI: 10.1182/blood.v108.11.3170.3170.Peer-Reviewed Original ResearchBone marrow transplantationAllo-BMT recipientsAntigen presenting cellsHost antigen presenting cellsAllogeneic bone marrow transplantationAly/aly miceInduction of GVHDSecondary lymphoid tissuesPeyer's patchesAllo-BMTAly miceLymphoid tissueT cellsLittermate controlsDonor T cell activationDonor T cell expansionWild-type B6 recipientsAllo-stimulatory capacitySyngeneic BMT recipientsDonor T cellsOnly curative optionSeverity of GVHDBALB/c T cellsIFN-γ productionT cell expansion
2004
Allo-Antigen Expression on Both APCS and Tumor Is Required To Elicit an Effective GVL Response after Experimental Allogeneic BMT.
Reddy P, Maeda Y, Liu C, Dinarello C, Ferrara J. Allo-Antigen Expression on Both APCS and Tumor Is Required To Elicit an Effective GVL Response after Experimental Allogeneic BMT. Blood 2004, 104: 595. DOI: 10.1182/blood.v104.11.595.595.Peer-Reviewed Original ResearchDonor T cellsAntigen presenting cellsT cellsAllogeneic BMTHost antigen presenting cellsLeukemia/tumor effectClass ITarget tissuesComplete donor chimerismBone marrow chimerasMinor H antigensPro-inflammatory cytokinesMalignant target cellsMHC class ICytokine blockadeGVL effectTCD BMGVH reactionGVL responseHistologic presenceDonor chimerismTumor effectSecond tumorImmunotherapeutic potentialSyngeneic controlsHost γd T cells Exacerbate Experimental Acute Graft-Versus-Host Disease through Activation of Host Antigen Presenting Cells.
Maeda Y, Reddy P, Liu C, Bishop D, Ferrara J. Host γd T cells Exacerbate Experimental Acute Graft-Versus-Host Disease through Activation of Host Antigen Presenting Cells. Blood 2004, 104: 3045. DOI: 10.1182/blood.v104.11.3045.3045.Peer-Reviewed Original ResearchHost dendritic cellsDendritic cellsT cellsB6 hostsDonor T cell expansionHost antigen presenting cellsBALB/c donorsAcute Graft-VersusB6 dendritic cellsControl dendritic cellsFull-intensity conditioningWT dendritic cellsSeverity of GVHDDonor T cellsAllogeneic T cellsT cell expansionWild-type B6Spleen T cellsAntigen presenting cellsSplenic T cellsMHC class IICells 24 hrNew therapeutic targetsDisease target tissuesT cell receptorPerforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells.
Maeda Y, Levy R, Reddy P, Liu C, Teshima T, Ferrara J. Perforin and Fas Ligand Are Required for the Regulation of Alloreactive CD8+ T Cells. Blood 2004, 104: 3052. DOI: 10.1182/blood.v104.11.3052.3052.Peer-Reviewed Original ResearchDonor T cellsT cellsDonor CD8WT T cellsAlloreactive CD8Day 10Day 30Host antigen presenting cellsFas ligandSingle MHC class IHost dendritic cellsModel of graftT cell populationsAntigen presenting cellsT cell homeostasisFas ligand pathwayMHC class IAllogeneic CD8Bm1 miceLethal GVHDSevere GVHDSignificant GVHDHost diseaseBMT recipientsEpithelial target cells