2011
Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells
Yao L, Yan X, Dong H, Nelson D, Liu C, Li X. Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient Huh 7.5 cells. Virology Journal 2011, 8: 445. PMID: 21936899, PMCID: PMC3213043, DOI: 10.1186/1743-422x-8-445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineDEAD Box Protein 58DEAD-box RNA HelicasesGene ExpressionHepacivirusHepatocytesHumansInterferon Regulatory Factor-3Interferon-alphaInterferon-betaMiceProtein BiosynthesisProtein MultimerizationReal-Time Polymerase Chain ReactionReceptors, EstrogenReceptors, ImmunologicRecombinant Fusion ProteinsTranscription, GeneticVirus ReplicationConceptsAnti-HCV effectInterferon regulatory factor 3Huh-7.5 cellsEstrogen receptorPolymerase chain reactionHepatitis C virus infectionViral replicationC virus infectionMouse estrogen receptorHepatitis C viral replicationInterferon-stimulated gene expressionExpression of IFNHCV viral replicationHCV RNA replicationReal-time polymerase chain reactionEstrogen receptor agonistsExpression of ISGsRegulatory factor 3HCV IRES-dependent translation
2005
Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication
Zhu H, Butera M, Nelson D, Liu C. Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virology Journal 2005, 2: 80. PMID: 16146571, PMCID: PMC1232870, DOI: 10.1186/1743-422x-2-80.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiviral AgentsBase SequenceCell LineGenes, MHC Class IHepacivirusHepatitis CHumansInterferon Regulatory Factor-1Interferon Type IInterferon-alphaInterferon-Stimulated Gene Factor 3Interleukin-10InterleukinsJanus KinasesMolecular Sequence DataRNA, ViralSignal TransductionSTAT Transcription FactorsVirus ReplicationConceptsInterferon-stimulated genesIL-28AAntiviral activityAntiviral efficacyHuman hepatoma cellsSide effectsChronic hepatitis C viral infectionHepatitis C viral infectionViral RNA replicationAntiviral response ratesHCV subgenomic RNA replicationIFNα-based therapyGenotype 1 infectionHCV chronic infectionC viral infectionIL-10 receptorIL-10 treatmentHLA class IType I IFNJAK-STATRNA replicationDose-dependent mannerHepatoma cellsExpression of ISGsUndesirable side effects