Elevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant
Young C, Papiro T, Greenberg JH. Elevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant. Pediatric Nephrology 2022, 38: 1-2. PMID: 35982345, PMCID: PMC9388350, DOI: 10.1007/s00467-022-05712-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCOVID-19COVID-19 Drug TreatmentFemaleHumansKidney TransplantationRitonavirTacrolimusUnited StatesConceptsCOVID-19 infectionSupratherapeutic tacrolimus levelsTacrolimus levelsKidney transplantCase reportPediatric kidney transplant recipientsElevated tacrolimus levelsKidney transplant recipientsPotent CYP3A4 inhibitorEmergency use authorizationDrug-drug interactionsPaucity of dataCytochrome P450 systemImmunosuppressant medicationsTransplant recipientsSerum creatininePediatric patientsCalcineurin inhibitorsKidney functionCYP3A4 inhibitorsConcomitant useTacrolimusTherapeutic goalsRitonavirDrug Administration