2023
Does This Child With High Blood Pressure Have Secondary Hypertension?
Nugent J, Jiang K, Funaro M, Saran I, Young C, Ghazi L, Bakhoum C, Wilson F, Greenberg J. Does This Child With High Blood Pressure Have Secondary Hypertension? JAMA 2023, 329: 1012-1021. PMID: 36976276, DOI: 10.1001/jama.2023.3184.Peer-Reviewed Original ResearchConceptsBlood pressure loadAmbulatory blood pressure monitoringSecondary hypertensionBlood pressure monitoringPrimary hypertensionFamily historyBlood pressurePressure monitoringDiastolic blood pressure loadSystolic blood pressure loadSerum uric acid concentrationAmbulatory blood pressureHigh blood pressureHistory of prematurityPrimary care clinicsRisk of biasNumber of patientsDatabases of MEDLINEDiagnostic Accuracy Studies toolLower body weightRandom-effects modelingUric acid concentrationWeb of ScienceLikelihood ratioAsymptomatic presentation
2022
Elevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant
Young C, Papiro T, Greenberg JH. Elevated tacrolimus levels after treatment with nirmatrelvir/ritonavir (Paxlovid) for COVID-19 infection in a child with a kidney transplant. Pediatric Nephrology 2022, 38: 1-2. PMID: 35982345, PMCID: PMC9388350, DOI: 10.1007/s00467-022-05712-0.Peer-Reviewed Original ResearchConceptsCOVID-19 infectionSupratherapeutic tacrolimus levelsTacrolimus levelsKidney transplantCase reportPediatric kidney transplant recipientsElevated tacrolimus levelsKidney transplant recipientsPotent CYP3A4 inhibitorEmergency use authorizationDrug-drug interactionsPaucity of dataCytochrome P450 systemImmunosuppressant medicationsTransplant recipientsSerum creatininePediatric patientsCalcineurin inhibitorsKidney functionCYP3A4 inhibitorsConcomitant useTacrolimusTherapeutic goalsRitonavirDrug AdministrationPrevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis
Nugent JT, Young C, Funaro MC, Jiang K, Saran I, Ghazi L, Wilson FP, Greenberg JH. Prevalence of Secondary Hypertension in Otherwise Healthy Youths with a New Diagnosis of Hypertension: A Meta-Analysis. The Journal Of Pediatrics 2022, 244: 30-37.e10. PMID: 35120981, PMCID: PMC9086113, DOI: 10.1016/j.jpeds.2022.01.047.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildHumansHypertensionMass ScreeningPrevalenceProspective StudiesRetrospective StudiesConceptsSecondary hypertensionPrimary careLow prevalenceNew diagnosisTime of diagnosisClinical practice guidelinesCochrane Library databasesBlood pressure deviceSignificant subgroup differencesParticipants' age rangeWeb of ScienceHypertension definitionReferral clinicProspective studyRetrospective studyOutpatient settingHealthy childrenSecondary causesCurrent guidelinesDiagnostic evaluationHypertensionObservational studyPractice guidelinesLibrary databasesPrevalence estimates