Multifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3.
Fan J, Cheney P, Bloch S, Xu B, Liang K, Odonkor C, Edwards W, Basak S, Mintz R, Biswas P, Achilefu S. Multifunctional Thio-Stabilized Gold Nanoparticles for Near-Infrared Fluorescence Detection and Imaging of Activated Caspase-3. Current Analytical Chemistry 2021, 17: 1182-1193. PMID: 34393690, PMCID: PMC8356907, DOI: 10.2174/1573411017999210112175743.Peer-Reviewed Original ResearchNIR fluorescent probeSpherical AuNPsGold nanoparticlesFluorescent probeAqueous mediaFluorescence enhancementDetection sensitivityNIR fluorescence enhancementTransmission electron microscopyFluorescence quenching efficiencyDye-labeled peptidesSignificant fluorescence enhancementFluorescence-quenching propertyRGD peptide sequenceActivatable NIR fluorescent probeHigh detection sensitivityFluorescence molecular probesNIR fluorescence spectroscopyMultifunctional AuNPsInfrared (NIR) fluorescent probeMultifunctional constructsNIR laser sourcePeptide sequencesOrganic dyesAuNPs