2008
Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
Guller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Severe preeclampsiaReperfusion injurySFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Ischemia/reperfusion injuryLife-threatening syndromeSubsequent reperfusion injuryTerm control groupPathophysiology of preeclampsiaTyrosine kinase-1Activator inhibitor-1Release of factorsSignificant increasePresence of mRNAUpregulation of mRNACeruloplasmin mRNAPlacental damagePlacental factorsMicroarray gene profilingEndothelium dysfunctionPE placentasQuantitative real-time PCRIntervillous spacePreeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells
Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F. Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells. American Journal Of Pathology 2008, 172: 1571-1579. PMID: 18467705, PMCID: PMC2408417, DOI: 10.2353/ajpath.2008.070629.Peer-Reviewed Original ResearchConceptsIL-6 levelsIL-6Decidual cellsGestational age-matched control placentasElevated IL-6 levelsIL-6 mRNA levelsCommon pregnancy disorderGenesis of preeclampsiaUteroplacental blood flowFetal-placental unitInterleukin-6 levelsPathogenesis of preeclampsiaPro-inflammatory cytokinesEndothelial cell dysfunctionInterleukin-6 expressionHuman decidual cellsReal-time quantitative RT-PCRTime quantitative RT-PCRQuantitative RT-PCRFetal morbidityDecidual macrophagesPreeclamptic womenSystemic inflammationPregnancy disordersControl placentas
1998
The effect of fetal intravascular blood transfusion on plasma endothelin levels in fetuses with rhesus alloimmunization.
Radunovic N, Nastic D, Rebarber A, Kuczynski E, Lockwood C. The effect of fetal intravascular blood transfusion on plasma endothelin levels in fetuses with rhesus alloimmunization. Obstetrics And Gynecology 1998, 91: 956-60. PMID: 9611003, DOI: 10.1016/s0029-7844(98)00073-8.Peer-Reviewed Original ResearchConceptsEndothelin levelsFetal transfusionPost-transfusionTransfusion of packed red blood cellsFetal umbilical venous bloodVolume of transfused bloodPacked red blood cellsAlloimmune hemolytic anemiaIntravascular blood transfusionIntravascular fetal transfusionPost-transfusion hematocritPost-transfusion increaseUmbilical vein pressureUmbilical venous pressureUmbilical venous bloodPlasma endothelin levelsPost-transfusion measurementsRhesus alloimmunizationGestational ageBlood transfusionIntravascular volumeRed blood cellsEndothelin concentrationsHemolytic anemiaTransfusion