Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells1
Lockwood CJ, Oner C, Uz YH, Kayisli UA, Huang SJ, Buchwalder LF, Murk W, Funai EF, Schatz F. Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells1. Biology Of Reproduction 2008, 78: 1064-1072. PMID: 18276934, PMCID: PMC3045968, DOI: 10.1095/biolreprod.107.063743.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCase-Control StudiesCells, CulturedDeciduaDNA PrimersEnzyme InductionFemaleHumansImmunohistochemistryInterleukin-1betaMatrix Metalloproteinase 2Matrix Metalloproteinase 9Pre-EclampsiaPregnancyPregnancy Trimester, FirstReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2Tumor Necrosis Factor-alphaConceptsTumor necrosis factor alphaNecrosis factor alphaInterleukin-1 betaMedroxyprogesterone acetateFactor alphaDecidual cellsMMP9 levelsExtravillous trophoblastsEVT invasionFirst trimester decidual cellsAge-matched control womenMatrix metalloproteinase-9 expressionUteroplacental blood flowLevels of MMP9Metalloproteinase-9 expressionMatrix metalloproteinases 1Matrix metalloproteinases 2Levels of MMP2Decidual extracellular matrixConcentration-dependent increaseSubstrate gel zymographyPreeclamptic deciduaQuantitative RT-PCRInterstitial trophoblastSpiral arteries