2009
Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells
Lockwood CJ, Murk W, Kayisli UA, Buchwalder LF, Huang S, Funai EF, Krikun G, Schatz F. Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 2164-2170. PMID: 19276228, PMCID: PMC2690421, DOI: 10.1210/jc.2009-0065.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedDeciduaFemaleGene Expression RegulationHumansInterleukin-1betaMedroxyprogesterone AcetatePregnancyProgestinsTerm BirthThrombinThromboplastinTumor Necrosis Factor-alphaConceptsMaternal-fetal interfaceTerm decidual cellsDecidual cellsTNF-alphaTissue factorPlacental sectionsTF mRNA levelsIL-1betaHuman maternal-fetal interfaceTF expressionWestern blottingTF levelsVillous mesenchymal cellsRT-PCRTerm placental sectionsMRNA levelsHigher histologic scoresTissue factor expressionIL-1beta effectReal-time RT-PCRQuantitative real-time RT-PCRDecidual sectionsHemostatic protectionPreterm deliveryQuantitative RT-PCR
2008
Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells1
Lockwood CJ, Oner C, Uz YH, Kayisli UA, Huang SJ, Buchwalder LF, Murk W, Funai EF, Schatz F. Matrix Metalloproteinase 9 (MMP9) Expression in Preeclamptic Decidua and MMP9 Induction by Tumor Necrosis Factor Alpha and Interleukin 1 Beta in Human First Trimester Decidual Cells1. Biology Of Reproduction 2008, 78: 1064-1072. PMID: 18276934, PMCID: PMC3045968, DOI: 10.1095/biolreprod.107.063743.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCase-Control StudiesCells, CulturedDeciduaDNA PrimersEnzyme InductionFemaleHumansImmunohistochemistryInterleukin-1betaMatrix Metalloproteinase 2Matrix Metalloproteinase 9Pre-EclampsiaPregnancyPregnancy Trimester, FirstReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2Tumor Necrosis Factor-alphaConceptsTumor necrosis factor alphaNecrosis factor alphaInterleukin-1 betaMedroxyprogesterone acetateFactor alphaDecidual cellsMMP9 levelsExtravillous trophoblastsEVT invasionFirst trimester decidual cellsAge-matched control womenMatrix metalloproteinase-9 expressionUteroplacental blood flowLevels of MMP9Metalloproteinase-9 expressionMatrix metalloproteinases 1Matrix metalloproteinases 2Levels of MMP2Decidual extracellular matrixConcentration-dependent increaseSubstrate gel zymographyPreeclamptic deciduaQuantitative RT-PCRInterstitial trophoblastSpiral arteries