Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
Guller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Severe preeclampsiaReperfusion injurySFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Ischemia/reperfusion injuryLife-threatening syndromeSubsequent reperfusion injuryTerm control groupPathophysiology of preeclampsiaTyrosine kinase-1Activator inhibitor-1Release of factorsSignificant increasePresence of mRNAUpregulation of mRNACeruloplasmin mRNAPlacental damagePlacental factorsMicroarray gene profilingEndothelium dysfunctionPE placentasQuantitative real-time PCRIntervillous spaceDecidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis
Lockwood CJ, Krikun G, Caze R, Rahman M, Buchwalder LF, Schatz F. Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis. Annals Of The New York Academy Of Sciences 2008, 1127: 67-72. PMID: 18443332, DOI: 10.1196/annals.1434.013.Peer-Reviewed Original ResearchConceptsDecidual cell-expressed tissue factorUteroplacental blood flowVascular endothelial growth factorTissue factorDecidual cellsBlood flowFirst trimester decidual cellsGrowth factorPlacental growth factorProtease-activated receptorsSFlt-1 expressionEndothelial growth factorPredominant cell typeMaternal thrombophiliaMaternal morbidityDecidual hemorrhageSpiral arteriesHuman pregnancySFlt-1Trophoblast invasionVascular remodelingPreeclampsiaVEGF expressionExcess thrombinAngiogenic effects