2024
Vaginal Progesterone for the Prevention of Preterm Birth in Pregnancies with Short Cervix
Schenone C, Duncan J, Lockwood C. Vaginal Progesterone for the Prevention of Preterm Birth in Pregnancies with Short Cervix. Current Obstetrics And Gynecology Reports 2024, 14: 1. DOI: 10.1007/s13669-024-00408-8.Peer-Reviewed Original ResearchEfficacy of vaginal progesteroneVaginal progesteronePreterm birthShort cervixSingleton pregnanciesMid-trimester cervical lengthPrevention of preterm birthEffect of vaginal progesteroneVaginal progesterone gelPrevent preterm birthPrevent preterm laborReduce preterm birthPreterm birth rateVaginal micronized progesteroneMeta-analysesData meta-analysesProgesterone gelCervical lengthMultifetal gestationPreterm laborTwin gestationsEvidence-based recommendationsMicronized progesteroneObstetric historyProgesterone formulationDecidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts
de Assis V, Kayisli U, Ozmen A, Semerci N, Totary-Jain H, Pakasticali N, Halade G, Lockwood C, Guzeloglu-Kayisli O. Decidual Cells Block Inflammation-Mediated Inhibition of 15-Hydroxyprostaglandin Dehydrogenase in Trophoblasts. American Journal Of Pathology 2024, 194: 1724-1736. PMID: 38879084, DOI: 10.1016/j.ajpath.2024.05.005.Peer-Reviewed Original ResearchConditioned medium supernatantTerm decidual cellsDecidual cellsExtravillous trophoblastHPGD expressionGestational age-matched controlsHuman trophoblast stem cellsFetal membrane ruptureMaternal-fetal interfaceTrophoblast stem cellsAge-matched controlsDecidua parietalisCervical ripeningUterine quiescencePreterm birthUterine contractionsAnchoring villiPrimary trophoblastsParacrine mechanismsParacrine inhibitionPregnancy maintenanceIL-1BInactivate prostaglandinsStem cellsProstaglandin
2023
Pathogenesis and Prediction of Preterm Delivery
Kendle A, Buhimschi C, Lockwood C. Pathogenesis and Prediction of Preterm Delivery. 2023, 344-360. DOI: 10.1002/9781119636540.ch40.Peer-Reviewed Original ResearchPreterm birthPR expressionPlacental corticotropin-releasing hormonePrediction of PTBAdrenal (HPA) axis pathwayCorticotropin-releasing hormoneToll-like receptorsProtease-activated receptorsPreterm deliveryProgesterone receptor inhibitorsDecidual hemorrhageInflammatory cascadeProinflammatory cytokinesInflammatory chemokinesProgesterone activityInterleukin-1βSonographic markersReceptor inhibitorsCortisol releaseInflammation pathwaysMatrix metalloproteinasesAxis pathwayPremature activationBiochemical remodelingProgressive withdrawal