1997
Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field
Burman D, Bruce C. Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field. Journal Of Neurophysiology 1997, 77: 2252-2267. PMID: 9163356, DOI: 10.1152/jn.1997.77.5.2252.Peer-Reviewed Original ResearchConceptsFrontal eye fieldPrimate frontal eye fieldSaccadic eye movementsElectrical stimulationEye fieldFEF sitesFoveal receptive fieldsSuppression of saccadesLow-intensity stimulationEye movementsCentral fixation targetMemory-guided saccadesAppropriate saccadeCortex anteriorFEF projectionsContraversive saccadesAnterior bankIntracortical microstimulationStimulation trialsPremotor cortexEvidence of suppressionReflexive saccadesMacaque monkeysSubcortical regionsFrontal lobe damage
1996
Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system
Russo GS, Bruce CJ. Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system. Journal Of Neurophysiology 1996, 76: 825-848. PMID: 8871203, DOI: 10.1152/jn.1996.76.2.825.Peer-Reviewed Original ResearchConceptsSupplementary eye fieldPresaccadic activitySaccadic eye movementsSEF neuronsOculocentric coordinate systemEye fieldEccentric orbital positionEye positionEye movementsInitial eye positionBeginning of saccadesMemory saccade taskFixation pointCentral fixation pointOculocentric coordinatesVisual cue presentationMacaque monkeysOculomotor rangeRhesus monkeysCraniocentric coordinatesNeuronsSaccade directionVisual targetsStimulus directionSaccades
1994
Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field
Gottlieb J, MacAvoy M, Bruce C. Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field. Journal Of Neurophysiology 1994, 72: 1634-1653. PMID: 7823092, DOI: 10.1152/jn.1994.72.4.1634.Peer-Reviewed Original ResearchConceptsSmooth eye movementsFrontal eye fieldPursuit neuronsEye movementsEye fieldPosterior bankPursuit directionPrimate frontal eye fieldMonkey frontal eye fieldSmooth pursuit eye movementsDirectional tuningBroad directional tuningSaccadic eye movementsSmooth pursuit trackingPursuit cellsMost neuronsIntracortical microstimulationPursuit velocityFEF neuronsFEF regionSmooth pursuitRhesus monkeysRegion involvementNeuron responsesNeurons
1993
Topography of projections to the frontal lobe from the macaque frontal eye fields
Stanton G, Bruce C, Goldberg M. Topography of projections to the frontal lobe from the macaque frontal eye fields. The Journal Of Comparative Neurology 1993, 330: 286-301. PMID: 8491870, DOI: 10.1002/cne.903300209.Peer-Reviewed Original ResearchConceptsFrontal eye fieldArcuate sulcusFrontal lobePrincipal sulcusInjection siteEye fieldIpsilateral frontal lobeMacaque frontal eye fieldTopography of projectionsSaccadic eye movementsTracer injection siteFEF areaFEF projectionsAnterior wallPosterior wallSubcortical connectionsElectrical elicitationMedial partUpper limbMacaque monkeysCortical layersSmall saccadesDorsomedial convexitySulcusEye movementsEffect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fields
Russo G, Bruce C. Effect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fields. Journal Of Neurophysiology 1993, 69: 800-818. PMID: 8385196, DOI: 10.1152/jn.1993.69.3.800.Peer-Reviewed Original Research
1991
Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex
Funahashi S, Bruce C, Goldman-Rakic P. Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex. Journal Of Neurophysiology 1991, 65: 1464-1483. PMID: 1875255, DOI: 10.1152/jn.1991.65.6.1464.Peer-Reviewed Original ResearchConceptsSaccadic eye movementsSaccade-related activityPostsaccadic activityPS neuronsVGS taskPresaccadic activityContralateral visual fieldODR taskDorsolateral prefrontal cortexPrefrontal cortexEye movementsIpsilateral fieldPrincipal sulcusMonkey dorsolateral prefrontal cortexVertical meridianVisual fieldReciprocal response patternSingle neuron activityExcitatory responsesInhibitory responsesNeuronal activitySaccade taskNeuronsSaccade directionCortexSmooth-Pursuit Eye Movement Representation in the Primate Frontal Eye Field
MacAvoy M, Gottlieb J, Bruce C. Smooth-Pursuit Eye Movement Representation in the Primate Frontal Eye Field. Cerebral Cortex 1991, 1: 95-102. PMID: 1822728, DOI: 10.1093/cercor/1.1.95.Peer-Reviewed Original ResearchConceptsSmooth pursuit eye movementsFrontal eye fieldPrimate frontal eye fieldEye movementsEye fieldIpsilateral smooth pursuitElicit eye movementsSaccadic eye movementsElicited saccadesSmooth pursuitSuperficial lesionsExperimental lesionsTracking deficitsLesionsVentral regionSubstantial deficitsVisual motionMovement representationsDeficitsMicrostimulationNeurons
1990
Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal
Goldberg M, Bruce C. Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal. Journal Of Neurophysiology 1990, 64: 489-508. PMID: 2213128, DOI: 10.1152/jn.1990.64.2.489.Peer-Reviewed Original ResearchConceptsFrontal eye fieldDouble-step taskSaccadic eye movementsEye fieldPostsaccadic activitySecond saccadeEye movementsFirst saccadeMonkey frontal eye fieldRetinal coordinatesDouble-step paradigmRetina. 2Receptive fieldsMovement fieldsVisuomovement cellsCell receptive fieldsPresaccadic activityMovement cellsFlashed targetsSaccade signalOculomotor tasksNeuronsSingle neuronsSaccadesRetinal stimulationVisuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms
Funahashi S, Bruce C, Goldman-Rakic P. Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms. Journal Of Neurophysiology 1990, 63: 814-831. PMID: 2341879, DOI: 10.1152/jn.1990.63.4.814.Peer-Reviewed Original ResearchConceptsODR taskVisual cuesPrefrontal cortexVisual responsesVisual probe taskLocation of cuesPrincipal sulcusVisual fieldDelay-period activitySame visual stimuliPrimate Prefrontal NeuronsDirectional visual responsesPassive visual responsesPS neuronsTask-related activityProbe taskSaccadic eye movementsVisuospatial codingCue locationSingle neuron activityVisual stimuliBehavioral enhancementOculomotor paradigmsPhasic visual responsesPrefrontal neurons
1989
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi S, Bruce C, Goldman-Rakic P. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. Journal Of Neurophysiology 1989, 61: 331-349. PMID: 2918358, DOI: 10.1152/jn.1989.61.2.331.Peer-Reviewed Original ResearchConceptsDelay-period activityDorsolateral prefrontal cortexPS neuronsPrefrontal cortexPrincipal sulcusDirectional delay-period activityMonkey dorsolateral prefrontal cortexSpontaneous rateFrontal eye field regionOculomotor delayed-response taskSpatial memory functionPeriod activityCue directionSaccadic eye movementsOculomotor behaviorPrimate prefrontal cortexSubsequent delay periodTask-related activityVisual field locationsExcitatory responsesMost neuronsAnterior bankArcuate sulcusInhibitory responsesFixation target
1988
Frontal eye field efferents in the macaque monkey: I. Subcortical pathways and topography of striatal and thalamic terminal fields
Stanton G, Goldberg M, Bruce C. Frontal eye field efferents in the macaque monkey: I. Subcortical pathways and topography of striatal and thalamic terminal fields. The Journal Of Comparative Neurology 1988, 271: 473-492. PMID: 2454970, DOI: 10.1002/cne.902710402.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAutoradiographyBrain MappingCorpus StriatumEfferent PathwaysElectric StimulationEye MovementsHorseradish PeroxidaseMacacaMacaca fascicularisMacaca mulattaOculomotor MusclesThalamusVisual FieldsWheat Germ Agglutinin-Horseradish Peroxidase ConjugateWheat Germ AgglutininsConceptsFrontal eye fieldMedial dorsal nucleusTerminal fieldsInjection siteDorsal nucleusSubthalamic nucleusCaudate nucleusMacaque monkeysArea 6Thalamic terminal fieldsArea XSaccadic eye movementsAmplitude of saccadesPars parvicellularisSubthalamic pathwayInternal capsuleExternal capsuleThalamic nucleiAnterograde tracerVentrolateral partVentromedial partCaudate bodyDorsomedial portionSubcortical pathwaysCaudal partFrontal eye field efferents in the macaque monkey: II. Topography of terminal fields in midbrain and pons
Stanton G, Goldberg M, Bruce C. Frontal eye field efferents in the macaque monkey: II. Topography of terminal fields in midbrain and pons. The Journal Of Comparative Neurology 1988, 271: 493-506. PMID: 2454971, DOI: 10.1002/cne.902710403.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAutoradiographyBrain MappingEfferent PathwaysElectric StimulationEye MovementsHorseradish PeroxidaseMacacaMesencephalonOculomotor MusclesPonsRaphe NucleiSuperior ColliculiTegmentum MesencephaliWheat Germ Agglutinin-Horseradish Peroxidase ConjugateWheat Germ AgglutininsConceptsPontine reticular formationSuperior colliculusReticular formationTerminal patchesAbducens nucleusTerminal fieldsMacaque monkeysIpsilateral nucleus prepositus hypoglossiLateral mesencephalic reticular formationParamedian pontine reticular formationLarge terminal fieldIpsilateral superior colliculusNucleus prepositus hypoglossiMesencephalic reticular formationRostral superior colliculusFibers of passagePatches of labelVentrolateral pontine reticular formationParvicellular red nucleusSaccadic eye movementsCaudal superior colliculusNucleus of DarkschewitschFEF projectionsNucleus limitansVentrolateral sites
1987
The role of striate cortex in the guidance of eye movements in the monkey
Segraves M, Goldberg M, Deng S, Bruce C, Ungerleider L, Mishkin M. The role of striate cortex in the guidance of eye movements in the monkey. Journal Of Neuroscience 1987, 7: 3040-3058. PMID: 3668615, PMCID: PMC6569180, DOI: 10.1523/jneurosci.07-10-03040.1987.Peer-Reviewed Original ResearchConceptsInitiation of saccadesCentral fixation pointLatency of saccadesSaccadic eye movementsStriate cortexSmooth pursuitEye velocityEye movementsImpaired fieldSmooth pursuit eye velocityFixation pointStep-ramp stimuliPursuit eye velocityIntact visual systemCortical ablationOculomotor abnormalitiesStimulus velocityFoveal targetAccurate saccadesStationary stimuliCortexSaccadesMonkeysVisual hemifieldLong latency
1986
The role of the arcuate frontal eye fields in the generation of saccadic eye movements
Goldberg M, Bruce C. The role of the arcuate frontal eye fields in the generation of saccadic eye movements. Progress In Brain Research 1986, 64: 143-154. PMID: 3726143, DOI: 10.1016/s0079-6123(08)63409-3.Peer-Reviewed Original Research
1985
Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements
Bruce C, Goldberg M, Bushnell M, Stanton G. Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. Journal Of Neurophysiology 1985, 54: 714-734. PMID: 4045546, DOI: 10.1152/jn.1985.54.3.714.Peer-Reviewed Original ResearchConceptsFrontal eye fieldEye fieldArcuate sulcusPresaccadic neuronsSaccade directionArea 8Frontal eye field neuronsEye movementsBrodmann area 8Cortical gray matterSaccadic eye movementsAwake macaque monkeysArea 8APresaccadic activityAnterior bankVentrolateral portionDorsomedial portionElicited saccadesElectrical stimulationLarge saccadesMacaque monkeysGray matterElectrode penetrationsAnatomical correlatesSmall saccades