1990
[22] Double-Label [3H]2-Deoxyglucose and [14C]2-Deoxyglucose Method for Mapping Brain Activity Underlying Two Experimental Conditions in the Same Animal
Friedman H, Bruce C, Goldman-Rakic P. [22] Double-Label [3H]2-Deoxyglucose and [14C]2-Deoxyglucose Method for Mapping Brain Activity Underlying Two Experimental Conditions in the Same Animal. International Review Of Neurobiology 1990, 3: 389-412. DOI: 10.1016/b978-0-12-185255-9.50027-4.Peer-Reviewed Original ResearchSame animalsBrain metabolic activitySame brain sectionBrain activityMapping brain activitySubtle anatomical differencesBrain tissue sectionsBrain sectionsDouble-label protocolDeoxyglucose methodMetabolic activityExperimental animalsPatterns of activityAnimal comparisonsTissue sectionsBehavioral conditionsSeparate experimental conditionsAnatomical differencesAnimalsExperimental periodInjectionColumnar patternActivity
1989
Resolution of metabolic columns by a double-label 2-DG technique: interdigitation and coincidence in visual cortical areas of the same monkey
Friedman H, Bruce C, Goldman-Rakic P. Resolution of metabolic columns by a double-label 2-DG technique: interdigitation and coincidence in visual cortical areas of the same monkey. Journal Of Neuroscience 1989, 9: 4111-4121. PMID: 2687438, PMCID: PMC6569629, DOI: 10.1523/jneurosci.09-12-04111.1989.Peer-Reviewed Original ResearchConceptsOcular dominance columnsExtrastriate areas V2Same monkeysVisual cortical areasVisual areas V1Cortical visual areas V1Alternate eyesX-ray filmsDouble-label methodMonocular crescentOptic discCortical areasMetabolic activitySeparate animalsArea V2Area V1Cortical columnsMetabolic differencesEyesMonkeysSame sectionPresent studyDifferential sensitivitySame subjectsV1
1987
A sequential double-label 14C- and 3H-2-DG technique: validation by double-dissociation of functional states
Friedman H, Bruce C, Goldman-Rakic P. A sequential double-label 14C- and 3H-2-DG technique: validation by double-dissociation of functional states. Experimental Brain Research 1987, 66: 543-554. PMID: 3609200, DOI: 10.1007/bf00270687.Peer-Reviewed Original ResearchConceptsDose ratioFunctional stateX-ray filmsBrain metabolismDouble-label methodBrain sectionsOwn controlSame animalsTreatmentInjectionComputerized imaging systemUltrofilmSame subjectsUptake patternsMetabolic activityInitial studyAutoradiogramsSubjectsDifferent functional statesUptakeExperimental treatmentsDifferent treatmentsRatsActivityCases