2005
SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells
de la Rosa D, Gimenez I, Forbush B, Canessa CM. SGK1 activates Na+-K+-ATPase in amphibian renal epithelial cells. American Journal Of Physiology - Cell Physiology 2005, 290: c492-c498. PMID: 16192298, DOI: 10.1152/ajpcell.00556.2004.Peer-Reviewed Original ResearchConceptsRenal epithelial cellsEpithelial cellsEffects of aldosteroneCell linesActivation of ENaCGlucocorticoid-induced kinase 1Epithelial cell lineRenal epithelial cell lineAldosteroneSGK1 expressionSame cell lineSubunit abundanceSGK1Channel activityTotal proteinImportant regulatorKinase 1Tetracycline-inducible promoterActivationCellsApical membraneATPase activityPrevious studiesATPase functionChronic
1995
Lung epithelial Na channel subunits are differentially regulated during development and by steroids
Tchepichev S, Ueda J, Canessa C, Rossier B, O'Brodovich H. Lung epithelial Na channel subunits are differentially regulated during development and by steroids. American Journal Of Physiology 1995, 269: c805-c812. PMID: 7573414, DOI: 10.1152/ajpcell.1995.269.3.c805.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAgingAnimalsAnimals, NewbornDexamethasoneEmbryonic and Fetal DevelopmentEpitheliumFetusLungRatsSodium ChannelsSodium-Potassium-Exchanging ATPaseThyrotropin-Releasing HormoneConceptsThyroid-releasing hormoneDays gestationFirst weekGamma-rENaC mRNANormal rat fetusesAlpha-rENaCMRNA levelsNa channelsNormal rat pupsEpithelial Na channelLate fetal gestationExpression of alphaCorticosteroid therapyCorticosteroid resistanceLung's abilityPregnant ratsRat pupsAdult ratsFetal lungRat fetusesPostnatal patternGlucocorticosteroid levelsFetal gestationGestationExpression correlatesLabeling of a cysteine in the cardiotonic glycoside binding site by the steroid derivative HDMA
Antolovic R, Schoner W, Geering K, Canessa C, Rossier B, Horisberger J. Labeling of a cysteine in the cardiotonic glycoside binding site by the steroid derivative HDMA. FEBS Letters 1995, 368: 169-172. PMID: 7615075, DOI: 10.1016/0014-5793(95)00637-o.Peer-Reviewed Original ResearchAffinity LabelsAnimalsCysteineDigoxigeninMutationRecombinant ProteinsSodium-Potassium-Exchanging ATPaseSuccinimidesXenopus
1993
Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance.
Canessa C, Horisberger J, Rossier B. Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase alpha subunit confers ouabain resistance. Journal Of Biological Chemistry 1993, 268: 17722-17726. PMID: 8394348, DOI: 10.1016/s0021-9258(17)46764-0.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsBase SequenceBinding SitesCell LineCloning, MolecularDogsFemaleKidneyKineticsMacromolecular SubstancesMolecular Sequence DataMutagenesis, Site-DirectedOligodeoxyribonucleotidesOocytesOuabainPeptide FragmentsPolymerase Chain ReactionProtein ConformationRecombinant ProteinsSequence Homology, Amino AcidSodium-Potassium-Exchanging ATPaseTime FactorsXenopus laevis
1992
Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump.
Jaisser F, Canessa C, Horisberger J, Rossier B. Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump. Journal Of Biological Chemistry 1992, 267: 16895-16903. PMID: 1380956, DOI: 10.1016/s0021-9258(18)41869-8.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernBufo marinusCell LineCloning, MolecularFemaleGene LibraryHumansIsoenzymesMacromolecular SubstancesMolecular Sequence DataOligodeoxyribonucleotidesOligonucleotides, AntisenseOocytesOuabainPotassiumRecombinant ProteinsRNASequence Homology, Nucleic AcidSodium-Potassium-Exchanging ATPaseTranscription, GeneticUrinary BladderXenopus laevisConceptsOuabain-resistant phenotypeAlpha 1 isoformBeta subunitAmino acidsK-ATPase alphaBeta 1Alpha 1Alpha 1 beta 1Oocyte expression systemXenopus laevis oocyte expression systemSequence comparisonBladder cell linesK pumpTerminal borderC-terminusExtracellular potassium ionsPrimary sequenceExpression systemMolecular mechanismsOuabain resistanceBeta 3 isoformsOuabain-resistant NaExtracellular loopFunctional expressionSubunitsMutation of a cysteine in the first transmembrane segment of Na,K‐ATPase alpha subunit confers ouabain resistance.
Canessa C, Horisberger J, Louvard D, Rossier B. Mutation of a cysteine in the first transmembrane segment of Na,K‐ATPase alpha subunit confers ouabain resistance. The EMBO Journal 1992, 11: 1681-1687. PMID: 1316269, PMCID: PMC556624, DOI: 10.1002/j.1460-2075.1992.tb05218.x.Peer-Reviewed Original Research