2005
Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel
Coric T, Zheng D, Gerstein M, Canessa CM. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel. The Journal Of Physiology 2005, 568: 725-735. PMID: 16002453, PMCID: PMC1464184, DOI: 10.1113/jphysiol.2005.087734.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion ChannelsAmino Acid SequenceAmino AcidsAnimalsEvolution, MolecularFishesHydrogen-Ion ConcentrationIon Channel GatingMembrane ProteinsMolecular Sequence DataNerve Tissue ProteinsProtein Structure, TertiaryProtonsSequence Homology, Amino AcidSodium ChannelsSpecies SpecificityStructure-Activity RelationshipConceptsAmino acid conservationChanges of residuesProton sensitivityMammalian nervous systemChordate lineageEarly vertebratesFunctional chimerasMammalian counterpartsLower vertebratesAllosteric changesProtein sequencesExtracellular domainSequence analysisDifferent speciesRat sequenceRat channelKinetics of activationStructural determinantsDistinct kineticsVertebratesASIC1 channelsMembrane potentialChimerasSharksEctodomain
1998
Structure and function of the Mec-ENaC family of ion channels.
Fyfe G, Quinn A, Canessa C. Structure and function of the Mec-ENaC family of ion channels. Seminars In Nephrology 1998, 18: 138-51. PMID: 9541269.Peer-Reviewed Original ResearchMeSH KeywordsEpithelial Sodium ChannelsEvolution, MolecularHumansIon Channel GatingSodium ChannelsStructure-Activity RelationshipConceptsIon channelsLittle amino acid identityCell type-dependent expressionAmino acid identityAcid identityDistinct tissuesEpithelial sodium channelFunction mutationsRecent discoveryProteinDifferential sensitivitySodium channelsSpecialized neuronsNew familyNociceptive painBlood pressureFamilyTissue injurySodium homeostasisSame common structureCommon ailmentsMechanical stimuliCloningTransductionDiuretic amiloride