1994
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
Canessa C, Schild L, Buell G, Thorens B, Gautschi I, Horisberger J, Rossier B. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature 1994, 367: 463-467. PMID: 8107805, DOI: 10.1038/367463a0.Peer-Reviewed Original ResearchConceptsEpithelial sodium channelRat epithelial sodium channelSodium channelsSodium reabsorptionSodium balanceDistal colonAmiloride-sensitive epithelial sodium channelPharmacological profileBlood volumeRenal tubulesRat epithelialExocrine glandsEpithelial cellsΑ-subunitDistal partNative channelsExpression cloningAldosteroneLungColon
1993
Expression of the epithelial Na+ channel in the developing rat lung
O'Brodovich H, Canessa C, Ueda J, Rafii B, Rossier B, Edelson J. Expression of the epithelial Na+ channel in the developing rat lung. American Journal Of Physiology 1993, 265: c491-c496. PMID: 7690185, DOI: 10.1152/ajpcell.1993.265.2.c491.Peer-Reviewed Original ResearchConceptsFetal lungAlveolar epitheliumRat lungAdult lungThyroid-releasing hormoneRat colonic epitheliumAlpha-rENaCWhole rat lungRat whole kidneyCombined administrationPregnant ratsImmature lungLung alphaAlveolar spaceColonic epitheliumLower mRNA levelsWhole kidneyLungSaccular stageLung developmentAdult alveolar epitheliumPrimary culturesDays GAEpitheliumMRNA levels