1994
Chapter 4 Structure–Function Relationship of Na,K-ATPase: The Digitalis Receptor
Canessa C, Jaisser F, Horisberger J, Rossier B. Chapter 4 Structure–Function Relationship of Na,K-ATPase: The Digitalis Receptor. Current Topics In Membranes 1994, 41: 71-85. DOI: 10.1016/s0070-2161(08)60454-2.Peer-Reviewed Original ResearchStructure-function relationshipsAmino acidsFirst transmembrane domainSite-directed mutagenesisK-ATPaseAmino acid residuesOuabain-sensitive cellsFunctional mutantsTransmembrane domainCellular processesDrug-binding sitesAromatic amino acidsDigitalis receptorWild typeContact sitesRandom mutationsOuabain resistanceΑ-subunitAcid residuesSite-specific ligandsFunctional assaysCardiac glycosidesCell linesOuabain analoguesK-ATPase activity
1992
Mutation of a cysteine in the first transmembrane segment of Na,K‐ATPase alpha subunit confers ouabain resistance.
Canessa C, Horisberger J, Louvard D, Rossier B. Mutation of a cysteine in the first transmembrane segment of Na,K‐ATPase alpha subunit confers ouabain resistance. The EMBO Journal 1992, 11: 1681-1687. PMID: 1316269, PMCID: PMC556624, DOI: 10.1002/j.1460-2075.1992.tb05218.x.Peer-Reviewed Original Research