2018
Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes
ELSHAFIE A, LAM W, PARIKH L, RANGEL E, SCHMIDT C, HWANG J, YECKEL C, SHERWIN R, BELFORT-DEAGUIAR R. Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes. Diabetes 2018, 67 DOI: 10.2337/db18-82-lb.Peer-Reviewed Original ResearchGlucose infusion rateInsulin secretion-sensitivity index-2Beta-cell functionContinuous overlapping net glycemic actionGlucose variabilityContinuous glucose monitorT2D subjectsObese subjectsInsulin levelsGV indicesGlucose metabolismCell functionInsulin sensitivity indexType 2 diabetesGlycemic Risk AssessmentCGM indicesHealthy obesityMannKind CorporationHealthy obeseOB subjectsGlycemic excursionsInsulin resistanceIncremental AUCGlycemic variabilityRegeneron Pharmaceuticals
2009
Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women
DiPietro L, Dziura J, Yeckel CW. Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women. Diabetes Care 2009, 33: 165-167. PMID: 19808930, PMCID: PMC2797964, DOI: 10.2337/dc09-1365.Peer-Reviewed Original ResearchConceptsHepatic insulin resistanceOral glucose tolerance testAbdominal obesityGlucose tolerance testHealthy older womenInsulin resistanceOlder womenTolerance testLow-dose insulin infusionHepatic glucose productionGlucose excursionsInsulin infusionPlasma glucoseAbdominal circumferenceInsulin concentrationsInsulin suppressionMin postchallengeObesityGlycemic responseClamp techniqueGlucose productionWomenHyperglycemiaProduction suppressionPostchallenge
2007
Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance
Yeckel C, Gulanski B, Lopes M, Dziura J, Parish R, Sherwin R. Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance. The FASEB Journal 2007, 21: a575-a575. DOI: 10.1096/fasebj.21.5.a575.Peer-Reviewed Original ResearchSympathetic overactivityInsulin resistanceHeart rateWhole-body insulin sensitivity indexExercise heart rate recoveryHealthy young cohortMaximal fitness testInsulin sensitivity indexHeart rate recoveryAutonomic nervous systemInsulin sensitivity measurementsRecovery heart rateParasympathetic dysfunctionSympathetic withdrawalParasympathetic functionInsulin levelsMaximal exerciseExercise recoverySympathovagal balanceCardiovascular diseaseRate recoveryNervous systemOveractivityFitness testsYounger cohorts
2004
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert T, Tamborlane W, Taksali S, Yeckel C, Allen K, Lopes M, Savoye M, Morrison J, Sherwin R, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. Obstetrical & Gynecological Survey 2004, 59: 822-824. DOI: 10.1097/01.ogx.0000140472.10719.95.Peer-Reviewed Original ResearchDegree of obesityMetabolic syndromeC-reactive proteinInsulin resistanceType 2 diabetesCRP levelsGlucose toleranceIL-6Higher C-reactive proteinDegree of dyslipidemiaInsulin-resistant adultsImpaired glucose toleranceIndependent risk factorInterleukin-6 levelsSystolic blood pressureBody mass indexAdvanced cardiovascular diseaseProportion of subjectsHigh-density lipoproteinVascular complicationsAdiponectin levelsBlood pressureObese subjectsMass indexNonobese individualsThe Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance
Yeckel CW, Taksali SE, Dziura J, Weiss R, Burgert TS, Sherwin RS, Tamborlane WV, Caprio S. The Normal Glucose Tolerance Continuum in Obese Youth: Evidence for Impairment in β-Cell Function Independent of Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 747-754. PMID: 15522932, DOI: 10.1210/jc.2004-1258.Peer-Reviewed Original ResearchConceptsBeta-cell responsivenessNormal glucose tolerancePlasma glucose levelsGlucose levelsGlucose toleranceInsulin sensitivityPlasma glucoseObese youthOral glucose tolerance testType 2 diabetes mellitusDecreased insulinogenic indexGlucose tolerance continuumGlucose tolerance testInsulin sensitivity indexContinuum of riskDelta insulinInsulinogenic indexDiabetes mellitusInsulin resistancePlasma levelsTolerance testNormal rangeFunction IndependentDlGlucose concentrationObesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultChildChild, PreschoolC-Reactive ProteinFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesityValidation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents
Yeckel CW, Weiss R, Dziura J, Taksali SE, Dufour S, Burgert TS, Tamborlane WV, Caprio S. Validation of Insulin Sensitivity Indices from Oral Glucose Tolerance Test Parameters in Obese Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 1096-1101. PMID: 15001593, DOI: 10.1210/jc.2003-031503.Peer-Reviewed Original ResearchConceptsWhole-body insulin sensitivity indexOral glucose tolerance testInsulin sensitivity indexIntramyocellular lipid contentInsulin sensitivityInsulin resistanceObese youthLarge cohortComposite whole body insulin sensitivity indexOral glucose tolerance test parametersSurrogate indexClamp-derived insulin sensitivityImpaired glucose toleranceGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampInsulin sensitivity measurementsGlucose toleranceMetabolic syndromeObese childrenObese populationPoor functionPlasma glucoseTolerance testInsulin response